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Page 1
Inflammasome activation in infected macrophages drives COVID-19 pathology.
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez S, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Sefik E, et al. Among authors: nussenzweig m. bioRxiv [Preprint]. 2022 Apr 1:2021.09.27.461948. doi: 10.1101/2021.09.27.461948. bioRxiv. 2022. PMID: 34611663 Free PMC article. Updated. Preprint.
The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies.
Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen L, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath J, Franco J, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte O, Zhang Y, Snow A, Holland S, Biggs C, Moncada-Vélez M, Arias A, Lorenzo L, Boucherit S, Anglicheau D, Planas A, Haerynck F, Duvlis S, Nussbaum R, Ozcelik T, Keles S, Bousfiha A, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarstrom Q, Hammarstrom L, Dupont A, Kurolap A, Metz C, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros L, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye S, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann N, Shcherbina A, Lau YL, Leun… See abstract for full author list ➔ Manry J, et al. Among authors: nussenzweig m. Res Sq [Preprint]. 2022 Jan 14:rs.3.rs-1225906. doi: 10.21203/rs.3.rs-1225906/v1. Res Sq. 2022. PMID: 35043109 Free PMC article. Updated. Preprint.
HIV-1 Vpu restricts Fc-mediated effector functions in vivo.
Prévost J, Anand SP, Rajashekar JK, Zhu L, Richard J, Goyette G, Medjahed H, Gendron-Lepage G, Chen HC, Chen Y, Horwitz JA, Grunst MW, Zolla-Pazner S, Haynes BF, Burton DR, Flavell RA, Kirchhoff F, Hahn BH, Smith AB 3rd, Pazgier M, Nussenzweig MC, Kumar P, Finzi A. Prévost J, et al. Among authors: nussenzweig mc. Cell Rep. 2022 Nov 8;41(6):111624. doi: 10.1016/j.celrep.2022.111624. Cell Rep. 2022. PMID: 36351384 Free PMC article.
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.
Jette CA, Cohen AA, Gnanapragasam PNP, Muecksch F, Lee YE, Huey-Tubman KE, Schmidt F, Hatziioannou T, Bieniasz PD, Nussenzweig MC, West AP Jr, Keeffe JR, Bjorkman PJ, Barnes CO. Jette CA, et al. bioRxiv [Preprint]. 2021 Apr 26:2021.04.23.441195. doi: 10.1101/2021.04.23.441195. bioRxiv. 2021. PMID: 33948592 Free PMC article. Updated. Preprint.
SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity.
Zhang F, Schmidt F, Muecksch F, Wang Z, Gazumyan A, Nussenzweig MC, Gaebler C, Caskey M, Hatziioannou T, Bieniasz PD. Zhang F, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2023 Jun 30:2023.06.30.547241. doi: 10.1101/2023.06.30.547241. bioRxiv. 2023. PMID: 37425700 Free PMC article. Updated. Preprint.
Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies.
Greaney AJ, Starr TN, Barnes CO, Weisblum Y, Schmidt F, Caskey M, Gaebler C, Cho A, Agudelo M, Finkin S, Wang Z, Poston D, Muecksch F, Hatziioannou T, Bieniasz PD, Robbiani DF, Nussenzweig MC, Bjorkman PJ, Bloom JD. Greaney AJ, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2021 Mar 18:2021.03.17.435863. doi: 10.1101/2021.03.17.435863. bioRxiv. 2021. PMID: 33758856 Free PMC article. Updated. Preprint.
Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape.
Witte L, Baharani V, Schmidt F, Wang Z, Cho A, Raspe R, Guzman-Cardozo MC, Muecksch F, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD. Witte L, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2022 Aug 19:2022.08.17.504313. doi: 10.1101/2022.08.17.504313. bioRxiv. 2022. PMID: 36032981 Free PMC article. Updated. Preprint.
Plasma neutralization properties of the SARS-CoV-2 Omicron variant.
Schmidt F, Muecksch F, Weisblum Y, Da Silva J, Bednarski E, Cho A, Wang Z, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD. Schmidt F, et al. Among authors: nussenzweig mc. medRxiv [Preprint]. 2021 Dec 13:2021.12.12.21267646. doi: 10.1101/2021.12.12.21267646. medRxiv. 2021. PMID: 34931199 Free PMC article. Updated. Preprint.
Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain.
Yang L, Van Beek M, Wang Z, Muecksch F, Canis M, Hatziioannou T, Bieniasz PD, Nussenzweig MC, Chakraborty AK. Yang L, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2022 Aug 25:2022.08.24.505127. doi: 10.1101/2022.08.24.505127. bioRxiv. 2022. PMID: 36052368 Free PMC article. Updated. Preprint.
515 results