Walden H - Search Results

1

A mechanistic review of Parkin activation.

Gundogdu M, Tadayon R, Salzano G, Shaw GS, Walden H. Gundogdu M, et al. Among authors: walden h. Biochim Biophys Acta Gen Subj. 2021 Jun;1865(6):129894. doi: 10.1016/j.bbagen.2021.129894. Epub 2021 Mar 20. Biochim Biophys Acta Gen Subj. 2021. PMID: 33753174 Free article. Review.

2

Autoregulation of Parkin activity through its ubiquitin-like domain.

Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H. Chaugule VK, et al. Among authors: walden h. EMBO J. 2011 Jun 21;30(14):2853-67. doi: 10.1038/emboj.2011.204. EMBO J. 2011. PMID: 21694720 Free PMC article.

3

Regulation of Parkin E3 ubiquitin ligase activity.

Walden H, Martinez-Torres RJ. Walden H, et al. Cell Mol Life Sci. 2012 Sep;69(18):3053-67. doi: 10.1007/s00018-012-0978-5. Epub 2012 Apr 19. Cell Mol Life Sci. 2012. PMID: 22527713 Free PMC article. Review.

4

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Kondapalli C, et al. Among authors: walden h. Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080. Open Biol. 2012. PMID: 22724072 Free PMC article.

5

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.

Spratt DE, Martinez-Torres RJ, Noh YJ, Mercier P, Manczyk N, Barber KR, Aguirre JD, Burchell L, Purkiss A, Walden H, Shaw GS. Spratt DE, et al. Among authors: walden h. Nat Commun. 2013;4:1983. doi: 10.1038/ncomms2983. Nat Commun. 2013. PMID: 23770917 Free PMC article.

6

RBR E3 ubiquitin ligases: new structures, new insights, new questions.

Spratt DE, Walden H, Shaw GS. Spratt DE, et al. Among authors: walden h. Biochem J. 2014 Mar 15;458(3):421-37. doi: 10.1042/BJ20140006. Biochem J. 2014. PMID: 24576094 Free PMC article. Review.

7

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM. Kazlauskaite A, et al. Among authors: walden h. EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25. EMBO Rep. 2015. PMID: 26116755 Free PMC article.

8

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H. Kumar A, et al. Among authors: walden h. EMBO J. 2015 Oct 14;34(20):2506-21. doi: 10.15252/embj.201592337. Epub 2015 Aug 7. EMBO J. 2015. PMID: 26254304 Free PMC article.

9

Ubiquitin and Parkinson's disease through the looking glass of genetics.

Walden H, Muqit MM. Walden H, et al. Biochem J. 2017 Apr 13;474(9):1439-1451. doi: 10.1042/BCJ20160498. Biochem J. 2017. PMID: 28408429 Free PMC article. Review.

10

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.

Kumar A, Chaugule VK, Condos TEC, Barber KR, Johnson C, Toth R, Sundaramoorthy R, Knebel A, Shaw GS, Walden H. Kumar A, et al. Among authors: walden h. Nat Struct Mol Biol. 2017 May;24(5):475-483. doi: 10.1038/nsmb.3400. Epub 2017 Apr 17. Nat Struct Mol Biol. 2017. PMID: 28414322 Free PMC article.

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