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Chalcones and their B-aryl analogues as myeloperoxidase inhibitors: In silico, in vitro and ex vivo investigations.
Santos MBD, Carvalho Marques B, Miranda Ayusso G, Rocha Garcia MA, Chiquetto Paracatu L, Pauli I, Silva Bolzani V, Defini Andricopulo A, Farias Ximenes V, Zeraik ML, Regasini LO. Santos MBD, et al. Among authors: regasini lo. Bioorg Chem. 2021 May;110:104773. doi: 10.1016/j.bioorg.2021.104773. Epub 2021 Mar 2. Bioorg Chem. 2021. PMID: 33744807
Improvement of pro-oxidant capacity of protocatechuic acid by esterification.
Zeraik ML, Petrônio MS, Coelho D, Regasini LO, Silva DH, da Fonseca LM, Machado SA, Bolzani VS, Ximenes VF. Zeraik ML, et al. Among authors: regasini lo. PLoS One. 2014 Oct 23;9(10):e110277. doi: 10.1371/journal.pone.0110277. eCollection 2014. PLoS One. 2014. PMID: 25340774 Free PMC article.
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Passalacqua TG, Dutra LA, de Almeida L, Velásquez AM, Torres FA, Yamasaki PR, dos Santos MB, Regasini LO, Michels PA, Bolzani Vda S, Graminha MA. Passalacqua TG, et al. Among authors: regasini lo. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3342-5. doi: 10.1016/j.bmcl.2015.05.072. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26055530
The 2',4'-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species.
Passalacqua TG, Torres FA, Nogueira CT, de Almeida L, Del Cistia ML, dos Santos MB, Dutra LA, Bolzani VS, Regasini LO, Graminha MA, Marchetto R, Zottis A. Passalacqua TG, et al. Among authors: regasini lo. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3564-8. doi: 10.1016/j.bmcl.2015.06.085. Epub 2015 Jun 30. Bioorg Med Chem Lett. 2015. PMID: 26169126
Alkyl Protocatechuate-Loaded Nanostructured Lipid Systems as a Treatment Strategy for Paracoccidioides brasiliensis and Paracoccidioides lutzii In Vitro.
Medina-Alarcón KP, Singulani JL, Voltan AR, Sardi JCO, Petrônio MS, Santos MB, Polaquini CR, Regasini LO, Bolzani VS, da Silva DHS, Chorilli M, Mendes-Giannini MJS, Fusco-Almeida AM. Medina-Alarcón KP, et al. Among authors: regasini lo. Front Microbiol. 2017 Jun 12;8:1048. doi: 10.3389/fmicb.2017.01048. eCollection 2017. Front Microbiol. 2017. PMID: 28659880 Free PMC article.
Activity of 3'-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models.
Palanco AC, Lacorte Singulani J, Costa-Orlandi CB, Gullo FP, Strohmayer Lourencetti NM, Gomes PC, Ayusso GM, Dutra LA, Silva Bolzani VD, Regasini LO, Soares Mendes-Giannini MJ, Fusco-Almeida AM. Palanco AC, et al. Among authors: regasini lo. Future Microbiol. 2017 Oct;12:1123-1134. doi: 10.2217/fmb-2017-0062. Epub 2017 Sep 6. Future Microbiol. 2017. PMID: 28876122
113 results