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Persistent repression of tau in the brain using engineered zinc finger protein transcription factors.
Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, Zhang L, Goodwin A, Ledeboer A, Lam S, Ankoudinova I, Tran H, Scarlott N, Amora R, Surosky R, Miller JC, Robbins AB, Rebar EJ, Urnov FD, Holmes MC, Pooler AM, Riley B, Zhang HS, Hyman BT. Wegmann S, et al. Among authors: robbins ab. Sci Adv. 2021 Mar 19;7(12):eabe1611. doi: 10.1126/sciadv.abe1611. Print 2021 Mar. Sci Adv. 2021. PMID: 33741591 Free PMC article.
Tau reduction in aged mice does not impact Microangiopathy.
Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT. Bennett RE, et al. Acta Neuropathol Commun. 2020 Aug 18;8(1):137. doi: 10.1186/s40478-020-01014-4. Acta Neuropathol Commun. 2020. PMID: 32811565 Free PMC article.
Experimental evidence for the age dependence of tau protein spread in the brain.
Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT. Wegmann S, et al. Among authors: robbins ab. Sci Adv. 2019 Jun 26;5(6):eaaw6404. doi: 10.1126/sciadv.aaw6404. eCollection 2019 Jun. Sci Adv. 2019. PMID: 31249873 Free PMC article.
AAV-based delivery of RNAi targeting Ataxin-2 improves survival, strength, and pathology in mouse models of rapidly and slowly progressive sporadic ALS.
Amado DA, Robbins AB, Smith AR, Whiteman KR, Chillon Bosch G, Chen Y, Fuller JA, Izda A, Nelson S, Dichter AI, Monteys AM, Davidson BL. Amado DA, et al. Among authors: robbins ab. bioRxiv [Preprint]. 2024 Feb 2:2024.01.31.578314. doi: 10.1101/2024.01.31.578314. bioRxiv. 2024. PMID: 38352376 Free PMC article. Preprint.
37 results