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Persistent repression of tau in the brain using engineered zinc finger protein transcription factors.
Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, Zhang L, Goodwin A, Ledeboer A, Lam S, Ankoudinova I, Tran H, Scarlott N, Amora R, Surosky R, Miller JC, Robbins AB, Rebar EJ, Urnov FD, Holmes MC, Pooler AM, Riley B, Zhang HS, Hyman BT. Wegmann S, et al. Among authors: hyman bt. Sci Adv. 2021 Mar 19;7(12):eabe1611. doi: 10.1126/sciadv.abe1611. Print 2021 Mar. Sci Adv. 2021. PMID: 33741591 Free PMC article.
Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice.
DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. DaRocha-Souto B, et al. Among authors: hyman bt. J Neuropathol Exp Neurol. 2011 May;70(5):360-76. doi: 10.1097/NEN.0b013e318217a118. J Neuropathol Exp Neurol. 2011. PMID: 21487307 Free PMC article.
Studying synapses in human brain with array tomography and electron microscopy.
Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Kay KR, et al. Among authors: hyman bt. Nat Protoc. 2013;8(7):1366-80. doi: 10.1038/nprot.2013.078. Epub 2013 Jun 20. Nat Protoc. 2013. PMID: 23787894 Free PMC article.
Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.
Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Pooler AM, et al. Among authors: hyman bt. J Comp Neurol. 2013 Dec 15;521(18):4236-48. doi: 10.1002/cne.23411. J Comp Neurol. 2013. PMID: 23839581 Free PMC article.
833 results