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Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.
Elife. 2021 Mar 19;10:e58565. doi: 10.7554/eLife.58565.
Elife. 2021.
PMID: 33739284
Free PMC article.
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
Licata NV, Cristofani R, Salomonsson S, Wilson KM, Kempthorne L, Vaizoglu D, D'Agostino VG, Pollini D, Loffredo R, Pancher M, Adami V, Bellosta P, Ratti A, Viero G, Quattrone A, Isaacs AM, Poletti A, Provenzani A.
Licata NV, et al. Among authors: kempthorne l.
EMBO J. 2022 Jan 4;41(1):e105026. doi: 10.15252/embj.2020105026. Epub 2021 Nov 18.
EMBO J. 2022.
PMID: 34791698
Free PMC article.
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AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.
Soutar MPM, Kempthorne L, Miyakawa S, Annuario E, Melandri D, Harley J, O'Sullivan GA, Wray S, Hancock DC, Cookson MR, Downward J, Carlton M, Plun-Favreau H.
Soutar MPM, et al. Among authors: kempthorne l.
Sci Rep. 2018 Jun 11;8(1):8855. doi: 10.1038/s41598-018-26949-6.
Sci Rep. 2018.
PMID: 29891871
Free PMC article.
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FBS/BSA media concentration determines CCCP's ability to depolarize mitochondria and activate PINK1-PRKN mitophagy.
Soutar MPM, Kempthorne L, Annuario E, Luft C, Wray S, Ketteler R, Ludtmann MHR, Plun-Favreau H.
Soutar MPM, et al. Among authors: kempthorne l.
Autophagy. 2019 Nov;15(11):2002-2011. doi: 10.1080/15548627.2019.1603549. Epub 2019 May 7.
Autophagy. 2019.
PMID: 31060423
Free PMC article.
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Correction to: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.
Kempthorne L, Yoon H, Madore C, Smith S, Wszolek ZK, Rademakers R, Kim J, Butovsky O, Dickson DW.
Kempthorne L, et al.
Acta Neuropathol Commun. 2020 Jun 24;8(1):90. doi: 10.1186/s40478-020-00970-1.
Acta Neuropathol Commun. 2020.
PMID: 32580749
Free PMC article.
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Patient and Caregiver Satisfaction With the Brain Injury Rehabilitation: Improving the Transition Experience (BRITE) Intervention.
Moore M, Kempthorne L, Fann JR, Shulein O, Dams-O'Connor K, Kajankova M, Conrick KM, Seeliger J, Hoffman JM.
Moore M, et al. Among authors: kempthorne l.
J Head Trauma Rehabil. 2024 May 13. doi: 10.1097/HTR.0000000000000949. Online ahead of print.
J Head Trauma Rehabil. 2024.
PMID: 38758094
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Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.
Kempthorne L, Yoon H, Madore C, Smith S, Wszolek ZK, Rademakers R, Kim J, Butovsky O, Dickson DW.
Kempthorne L, et al.
Acta Neuropathol Commun. 2020 May 19;8(1):72. doi: 10.1186/s40478-020-00947-0.
Acta Neuropathol Commun. 2020.
PMID: 32430064
Free PMC article.
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