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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D. Liang YL, et al. Among authors: zhao p. Nature. 2018 Mar 1;555(7694):121-125. doi: 10.1038/nature25773. Epub 2018 Feb 21. Nature. 2018. PMID: 29466332
Activation of the GLP-1 receptor by a non-peptidic agonist.
Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D. Zhao P, et al. Nature. 2020 Jan;577(7790):432-436. doi: 10.1038/s41586-019-1902-z. Epub 2020 Jan 8. Nature. 2020. PMID: 31915381
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D. Liang YL, et al. Among authors: zhao p. Mol Cell. 2020 Feb 6;77(3):656-668.e5. doi: 10.1016/j.molcel.2020.01.012. Epub 2020 Jan 30. Mol Cell. 2020. PMID: 32004469 Free article.
Structural basis of Gs and Gi recognition by the human glucagon receptor.
Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B. Qiao A, et al. Among authors: zhao p, zhao q. Science. 2020 Mar 20;367(6484):1346-1352. doi: 10.1126/science.aaz5346. Science. 2020. PMID: 32193322
Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination.
Liang YL, Zhao P, Draper-Joyce C, Baltos JA, Glukhova A, Truong TT, May LT, Christopoulos A, Wootten D, Sexton PM, Furness SGB. Liang YL, et al. Among authors: zhao p. ACS Pharmacol Transl Sci. 2018 Jul 26;1(1):12-20. doi: 10.1021/acsptsci.8b00017. eCollection 2018 Sep 14. ACS Pharmacol Transl Sci. 2018. PMID: 32219201 Free PMC article.
9,023 results