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Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib.
Curr Oncol Rep. 2021 Mar 15;23(4):45. doi: 10.1007/s11912-021-01032-y.
Curr Oncol Rep. 2021.
PMID: 33721151
Free PMC article.
Review.
Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1.
Osum SH, Watson AL, Largaespada DA.
Osum SH, et al.
Int J Mol Sci. 2021 Feb 16;22(4):1954. doi: 10.3390/ijms22041954.
Int J Mol Sci. 2021.
PMID: 33669386
Free PMC article.
Review.
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Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo.
Osum SH, Coutts AW, Duerre DJ, Tschida BR, Kirstein MN, Fisher J, Bell WR, Delpuech O, Smith PD, Widemann BC, Moertel CL, Largaespada DA, Watson AL.
Osum SH, et al.
Neurooncol Adv. 2021 Feb 10;3(1):vdab020. doi: 10.1093/noajnl/vdab020. eCollection 2021 Jan-Dec.
Neurooncol Adv. 2021.
PMID: 33978635
Free PMC article.
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PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.
Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahrmann EP, Moriarity BS, Largaespada DA.
Smeester BA, et al. Among authors: osum sh.
Bone. 2020 Jul;136:115353. doi: 10.1016/j.bone.2020.115353. Epub 2020 Apr 3.
Bone. 2020.
PMID: 32251854
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Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny.
Ruscher R, Lee ST, Salgado OC, Breed ER, Osum SH, Hogquist KA.
Ruscher R, et al. Among authors: osum sh.
J Exp Med. 2020 Aug 3;217(8):e20192336. doi: 10.1084/jem.20192336.
J Exp Med. 2020.
PMID: 32687575
Free PMC article.
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Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1.
Osum SH, Oribamise EI, Corbière SMAS, Taisto M, Jubenville T, Coutts A, Kirstein MN, Fisher J, Moertel C, Du M, Bedwell D, Largaespada DA, Watson AL.
Osum SH, et al.
Mol Ther Nucleic Acids. 2023 Jun 26;33:227-239. doi: 10.1016/j.omtn.2023.06.018. eCollection 2023 Sep 12.
Mol Ther Nucleic Acids. 2023.
PMID: 37520682
Free PMC article.
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Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology.
Larsson AT, Bhatia H, Calizo A, Pollard K, Zhang X, Conniff E, Tibbitts JF, Rono E, Cummins K, Osum SH, Williams KB, Crampton AL, Jubenville T, Schefer D, Yang K, Lyu Y, Pino JC, Bade J, Gross JM, Lisok A, Dehner CA, Chrisinger JSA, He K, Gosline SJC, Pratilas CA, Largaespada DA, Wood DK, Hirbe AC.
Larsson AT, et al. Among authors: osum sh.
Neuro Oncol. 2023 Nov 2;25(11):2044-2057. doi: 10.1093/neuonc/noad097.
Neuro Oncol. 2023.
PMID: 37246765
Free PMC article.
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