Fearns A - Search Results

1

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation.

Queval CJ, Fearns A, Botella L, Smyth A, Schnettger L, Mitermite M, Wooff E, Villarreal-Ramos B, Garcia-Jimenez W, Heunis T, Trost M, Werling D, Salguero FJ, Gordon SV, Gutierrez MG. Queval CJ, et al. Among authors: fearns a. PLoS Pathog. 2021 Mar 15;17(3):e1009410. doi: 10.1371/journal.ppat.1009410. eCollection 2021 Mar. PLoS Pathog. 2021. PMID: 33720986 Free PMC article.

2

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells.

Lerner TR, Queval CJ, Fearns A, Repnik U, Griffiths G, Gutierrez MG. Lerner TR, et al. Among authors: fearns a. BMC Biol. 2018 Jan 4;16(1):1. doi: 10.1186/s12915-017-0471-6. BMC Biol. 2018. PMID: 29325545 Free PMC article.

3

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.

Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG. Härtlova A, et al. Among authors: fearns a. EMBO J. 2018 Jun 15;37(12):e98694. doi: 10.15252/embj.201798694. Epub 2018 May 22. EMBO J. 2018. PMID: 29789389 Free PMC article.

4

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity.

Lerner TR, Queval CJ, Lai RP, Russell MR, Fearns A, Greenwood DJ, Collinson L, Wilkinson RJ, Gutierrez MG. Lerner TR, et al. Among authors: fearns a. JCI Insight. 2020 May 21;5(10):e136937. doi: 10.1172/jci.insight.136937. JCI Insight. 2020. PMID: 32369443 Free PMC article.

5

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion.

Bernard EM, Fearns A, Bussi C, Santucci P, Peddie CJ, Lai RJ, Collinson LM, Gutierrez MG. Bernard EM, et al. Among authors: fearns a. J Cell Sci. 2020 Nov 25;134(5):jcs252973. doi: 10.1242/jcs.252973. J Cell Sci. 2020. PMID: 32938685 Free PMC article.

6

Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs.

Fearns A, Greenwood DJ, Rodgers A, Jiang H, Gutierrez MG. Fearns A, et al. PLoS Biol. 2020 Dec 31;18(12):e3000879. doi: 10.1371/journal.pbio.3000879. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33382684 Free PMC article.

7

[No title available]

[No authors listed] [No authors listed] PMID: 34005323

8

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide.

Santucci P, Greenwood DJ, Fearns A, Chen K, Jiang H, Gutierrez MG. Santucci P, et al. Among authors: fearns a. Nat Commun. 2021 Jun 21;12(1):3816. doi: 10.1038/s41467-021-24127-3. Nat Commun. 2021. PMID: 34155215 Free PMC article.

9

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.

Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG. Bussi C, et al. Among authors: fearns a. Nat Commun. 2022 Nov 28;13(1):7338. doi: 10.1038/s41467-022-34632-8. Nat Commun. 2022. PMID: 36443305 Free PMC article.

10

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages.

Aylan B, Bernard EM, Pellegrino E, Botella L, Fearns A, Athanasiadi N, Bussi C, Santucci P, Gutierrez MG. Aylan B, et al. Among authors: fearns a. Nat Microbiol. 2023 May;8(5):803-818. doi: 10.1038/s41564-023-01335-9. Epub 2023 Mar 23. Nat Microbiol. 2023. PMID: 36959508 Free PMC article.

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