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Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.
Acquaviva J, Jun HJ, Lessard J, Ruiz R, Zhu H, Donovan M, Woolfenden S, Boskovitz A, Raval A, Bronson RT, Pfannl R, Whittaker CA, Housman DE, Charest A. Acquaviva J, et al. Among authors: charest a. Cancer Res. 2011 Dec 1;71(23):7198-206. doi: 10.1158/0008-5472.CAN-11-1514. Epub 2011 Oct 10. Cancer Res. 2011. PMID: 21987724 Free PMC article.
ROS1 signaling regulates epithelial differentiation in the epididymis.
Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A. Jun HJ, et al. Among authors: charest a. Endocrinology. 2014 Sep;155(9):3661-73. doi: 10.1210/en.2014-1341. Epub 2014 Jun 27. Endocrinology. 2014. PMID: 24971615 Free PMC article.
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Zou HY, Li Q, Engstrom LD, West M, Appleman V, Wong KA, McTigue M, Deng YL, Liu W, Brooun A, Timofeevski S, McDonnell SR, Jiang P, Falk MD, Lappin PB, Affolter T, Nichols T, Hu W, Lam J, Johnson TW, Smeal T, Charest A, Fantin VR. Zou HY, et al. Among authors: charest a. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3493-8. doi: 10.1073/pnas.1420785112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733882 Free PMC article.
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.
Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A. Jun HJ, et al. Among authors: charest a. Nat Commun. 2018 Aug 6;9(1):3116. doi: 10.1038/s41467-018-05036-4. Nat Commun. 2018. PMID: 30082792 Free PMC article.
A high-grade glioma with SOS1 amplification.
Vidal B, Bryke C, Hsu N, Alterman R, Yeo AT, Charest A, Varma H. Vidal B, et al. Among authors: charest a. Clin Neuropathol. 2020 May/Jun;39(3):126-134. doi: 10.5414/NP301182. Clin Neuropathol. 2020. PMID: 31841105
111 results