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Molecular tweezers modulate 14-3-3 protein-protein interactions.
Bier D, Rose R, Bravo-Rodriguez K, Bartel M, Ramirez-Anguita JM, Dutt S, Wilch C, Klärner FG, Sanchez-Garcia E, Schrader T, Ottmann C. Bier D, et al. Nat Chem. 2013 Mar;5(3):234-9. doi: 10.1038/nchem.1570. Epub 2013 Feb 17. Nat Chem. 2013. PMID: 23422566
Molecular tweezers with varying anions: a comparative study.
Dutt S, Wilch C, Gersthagen T, Talbiersky P, Bravo-Rodriguez K, Hanni M, Sánchez-García E, Ochsenfeld C, Klärner FG, Schrader T. Dutt S, et al. J Org Chem. 2013 Jul 5;78(13):6721-34. doi: 10.1021/jo4009673. Epub 2013 Jun 18. J Org Chem. 2013. PMID: 23750919
A molecular tweezer antagonizes seminal amyloids and HIV infection.
Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J. Lump E, et al. Elife. 2015 Aug 18;4:e05397. doi: 10.7554/eLife.05397. Elife. 2015. PMID: 26284498 Free PMC article.
Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.
Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E. Vöpel T, et al. J Am Chem Soc. 2017 Apr 26;139(16):5640-5643. doi: 10.1021/jacs.6b11039. Epub 2017 Apr 13. J Am Chem Soc. 2017. PMID: 28406616 Free PMC article.
The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.
Bier D, Mittal S, Bravo-Rodriguez K, Sowislok A, Guillory X, Briels J, Heid C, Bartel M, Wettig B, Brunsveld L, Sanchez-Garcia E, Schrader T, Ottmann C. Bier D, et al. J Am Chem Soc. 2017 Nov 15;139(45):16256-16263. doi: 10.1021/jacs.7b07939. Epub 2017 Nov 2. J Am Chem Soc. 2017. PMID: 29039919 Free PMC article.
166 results