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WNT inhibition creates a BRCA-like state in Wnt-addicted cancer.
Kaur A, Lim JYS, Sepramaniam S, Patnaik S, Harmston N, Lee MA, Petretto E, Virshup DM, Madan B. Kaur A, et al. Among authors: virshup dm. EMBO Mol Med. 2021 Apr 9;13(4):e13349. doi: 10.15252/emmm.202013349. Epub 2021 Mar 4. EMBO Mol Med. 2021. PMID: 33660437 Free PMC article.
Updating the Wnt pathways.
Yu J, Virshup DM. Yu J, et al. Among authors: virshup dm. Biosci Rep. 2014 Oct 17;34(5):e00142. doi: 10.1042/BSR20140119. Biosci Rep. 2014. PMID: 25208913 Free PMC article.
TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.
Ribi S, Baumhoer D, Lee K, Edison, Teo AS, Madan B, Zhang K, Kohlmann WK, Yao F, Lee WH, Hoi Q, Cai S, Woo XY, Tan P, Jundt G, Smida J, Nathrath M, Sung WK, Schiffman JD, Virshup DM, Hillmer AM. Ribi S, et al. Among authors: virshup dm. Oncotarget. 2015 Apr 10;6(10):7727-40. doi: 10.18632/oncotarget.3115. Oncotarget. 2015. PMID: 25762628 Free PMC article.
Discovery and Optimization of a Porcupine Inhibitor.
Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, Virshup DM, Keller TH. Duraiswamy AJ, et al. Among authors: virshup dm. J Med Chem. 2015 Aug 13;58(15):5889-99. doi: 10.1021/acs.jmedchem.5b00507. Epub 2015 Jul 16. J Med Chem. 2015. PMID: 26110200
169 results