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Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression.
Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, Dean E, Hume C, Hayward S, Oliver J, Zhao FY, Spanswick D, Reynolds CA, Lochner M, Ladds G, Frenguelli BG. Wall MJ, et al. Among authors: winfield i. Nat Commun. 2022 Jul 18;13(1):4150. doi: 10.1038/s41467-022-31652-2. Nat Commun. 2022. PMID: 35851064 Free PMC article.
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.
Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds G. Knight A, et al. Among authors: winfield i. J Med Chem. 2016 Feb 11;59(3):947-64. doi: 10.1021/acs.jmedchem.5b01402. Epub 2016 Feb 1. J Med Chem. 2016. PMID: 26756468 Free article.
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.
Weston C, Winfield I, Harris M, Hodgson R, Shah A, Dowell SJ, Mobarec JC, Woodlock DA, Reynolds CA, Poyner DR, Watkins HA, Ladds G. Weston C, et al. Among authors: winfield i. J Biol Chem. 2016 Oct 14;291(42):21925-21944. doi: 10.1074/jbc.M116.751362. Epub 2016 Aug 26. J Biol Chem. 2016. PMID: 27566546 Free PMC article.
The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation.
Winfield I, Barkan K, Routledge S, Robertson NJ, Harris M, Jazayeri A, Simms J, Reynolds CA, Poyner DR, Ladds G. Winfield I, et al. Front Endocrinol (Lausanne). 2022 Jan 13;12:792912. doi: 10.3389/fendo.2021.792912. eCollection 2021. Front Endocrinol (Lausanne). 2022. PMID: 35095763 Free PMC article.
Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors.
Weston C, Winfield I, Harris M, Hodgson R, Shah A, Dowell SJ, Mobarec JC, Woodcock DA, Reynolds CA, Poyner DR, Watkins HA, Ladds G. Weston C, et al. Among authors: winfield i. J Biol Chem. 2016 Dec 2;291(49):25763. doi: 10.1074/jbc.A116.751362. J Biol Chem. 2016. PMID: 27913664 Free PMC article. No abstract available.
55 results