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Binding site for activator MDL-801 on SIRT6.
You W, Steegborn C. You W, et al. Among authors: steegborn c. Nat Chem Biol. 2021 May;17(5):519-521. doi: 10.1038/s41589-021-00749-y. Epub 2021 Mar 1. Nat Chem Biol. 2021. PMID: 33649599 No abstract available.
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, Chua KF, Mai A, Steegborn C. You W, et al. Among authors: steegborn c. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011. doi: 10.1002/anie.201610082. Epub 2016 Dec 19. Angew Chem Int Ed Engl. 2017. PMID: 27990725
A blue light receptor that mediates RNA binding and translational regulation.
Weber AM, Kaiser J, Ziegler T, Pilsl S, Renzl C, Sixt L, Pietruschka G, Moniot S, Kakoti A, Juraschitz M, Schrottke S, Lledo Bryant L, Steegborn C, Bittl R, Mayer G, Möglich A. Weber AM, et al. Among authors: steegborn c. Nat Chem Biol. 2019 Nov;15(11):1085-1092. doi: 10.1038/s41589-019-0346-y. Epub 2019 Aug 26. Nat Chem Biol. 2019. PMID: 31451761 Free PMC article.
Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin.
You W, Steegborn C. You W, et al. Among authors: steegborn c. ACS Med Chem Lett. 2020 Sep 24;11(11):2285-2289. doi: 10.1021/acsmedchemlett.0c00407. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214841 Free PMC article.
A molecular mechanism for direct sirtuin activation by resveratrol.
Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C. Gertz M, et al. Among authors: steegborn c. PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185430 Free PMC article.
133 results