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Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors.
Gonzaga DTG, Oliveira FH, von Ranke NL, Pinho GQ, Salles JP, Bello ML, Rodrigues CR, Castro HC, de Souza HVCM, Reis CRC, Leme RPP, Mafra JCM, Pinheiro LCS, Hoelz LVB, Boechat N, Faria RX. Gonzaga DTG, et al. Among authors: bello ml. Front Chem. 2019 Apr 30;7:261. doi: 10.3389/fchem.2019.00261. eCollection 2019. Front Chem. 2019. PMID: 31134177 Free PMC article.
P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones.
de Luna Martins D, Borges AA, E Silva NADA, Faria JV, Hoelz LVB, de Souza HVCM, Bello ML, Boechat N, Ferreira VF, Faria RX. de Luna Martins D, et al. Among authors: bello ml. Bioorg Chem. 2020 Nov;104:104278. doi: 10.1016/j.bioorg.2020.104278. Epub 2020 Sep 17. Bioorg Chem. 2020. PMID: 33010623
1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo.
Gonzaga DTG, Ferreira LBG, Moreira Maramaldo Costa TE, von Ranke NL, Anastácio Furtado Pacheco P, Sposito Simões AP, Arruda JC, Dantas LP, de Freitas HR, de Melo Reis RA, Penido C, Bello ML, Castro HC, Rodrigues CR, Ferreira VF, Faria RX, da Silva FC. Gonzaga DTG, et al. Among authors: bello ml. Eur J Med Chem. 2017 Oct 20;139:698-717. doi: 10.1016/j.ejmech.2017.08.034. Epub 2017 Aug 16. Eur J Med Chem. 2017. PMID: 28858765
1,4-Naphthoquinones potently inhibiting P2X7 receptor activity.
Faria RX, Oliveira FH, Salles JP, Oliveira AS, von Ranke NL, Bello ML, Rodrigues CR, Castro HC, Louvis AR, Martins DL, Ferreira VF. Faria RX, et al. Among authors: bello ml. Eur J Med Chem. 2018 Jan 1;143:1361-1372. doi: 10.1016/j.ejmech.2017.10.033. Epub 2017 Oct 23. Eur J Med Chem. 2018. PMID: 29133043
Synthesis, biological evaluation and molecular modeling studies of novel 1,2,3-triazole-linked menadione-furan derivatives as P2X7 inhibitors.
Dos Santos JPS, Ribeiro RCB, Faria JV, Bello ML, Lima CGS, Pauli FP, Borges AA, Rocha DR, Moraes MG, Forezi LSM, Ferreira VF, Faria RX, da Silva FC. Dos Santos JPS, et al. Among authors: bello ml. J Bioenerg Biomembr. 2022 Dec;54(5-6):227-239. doi: 10.1007/s10863-022-09947-2. Epub 2022 Sep 7. J Bioenerg Biomembr. 2022. PMID: 36070071
43 results