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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
Diesinger T, Lautwein A, Bergler S, Buckert D, Renz C, Dvorsky R, Buko V, Kirko S, Schneider E, Kuchenbauer F, Kumar M, Günes C, Genze F, Büchele B, Simmet T, Haslbeck M, Masur K, Barth T, Müller-Enoch D, Wirth T, Haehner T. Diesinger T, et al. Among authors: wirth t. Can J Gastroenterol Hepatol. 2021 Feb 2;2021:8854432. doi: 10.1155/2021/8854432. eCollection 2021. Can J Gastroenterol Hepatol. 2021. PMID: 33604316 Free PMC article.
Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis.
Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O, Naruta E, Kirko S, Andreev V, Buckert D, Bergler S, Renz C, Schneider E, Kuchenbauer F, Kumar M, Günes C, Büchele B, Simmet T, Müller-Enoch D, Wirth T, Haehner T. Diesinger T, et al. Among authors: wirth t. PLoS One. 2020 Jul 23;15(7):e0235990. doi: 10.1371/journal.pone.0235990. eCollection 2020. PLoS One. 2020. PMID: 32701948 Free PMC article.
MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.
Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler HA, Barth TF, Möller P, Stilgenbauer S, Pollack JR, Wirth T. Sander S, et al. Among authors: wirth t. Blood. 2008 Nov 15;112(10):4202-12. doi: 10.1182/blood-2008-03-147645. Epub 2008 Aug 19. Blood. 2008. PMID: 18713946 Free article.
Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.
Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M. Sunami Y, et al. Among authors: wirth t. Hepatology. 2016 May;63(5):1592-607. doi: 10.1002/hep.28435. Epub 2016 Mar 4. Hepatology. 2016. PMID: 26892811 Free article.
687 results