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Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.
Skwarski M, McGowan DR, Belcher E, Di Chiara F, Stavroulias D, McCole M, Derham JL, Chu KY, Teoh E, Chauhan J, O'Reilly D, Harris BHL, Macklin PS, Bull JA, Green M, Rodriguez-Berriguete G, Prevo R, Folkes LK, Campo L, Ferencz P, Croal PL, Flight H, Qi C, Holmes J, O'Connor JPB, Gleeson FV, McKenna WG, Harris AL, Bulte D, Buffa FM, Macpherson RE, Higgins GS. Skwarski M, et al. Among authors: mckenna wg. Clin Cancer Res. 2021 May 1;27(9):2459-2469. doi: 10.1158/1078-0432.CCR-20-4128. Epub 2021 Feb 17. Clin Cancer Res. 2021. PMID: 33597271 Free PMC article.
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy.
Ashton TM, McKenna WG, Kunz-Schughart LA, Higgins GS. Ashton TM, et al. Among authors: mckenna wg. Clin Cancer Res. 2018 Jun 1;24(11):2482-2490. doi: 10.1158/1078-0432.CCR-17-3070. Epub 2018 Feb 2. Clin Cancer Res. 2018. PMID: 29420223 Review.
Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma.
McGowan DR, Skwarski M, Bradley KM, Campo L, Fenwick JD, Gleeson FV, Green M, Horne A, Maughan TS, McCole MG, Mohammed S, Muschel RJ, Ng SM, Panakis N, Prevo R, Strauss VY, Stuart R, Tacconi EMC, Vallis KA, McKenna WG, Macpherson RE, Higgins GS. McGowan DR, et al. Among authors: mckenna wg. Eur J Cancer. 2019 May;113:87-95. doi: 10.1016/j.ejca.2019.03.015. Epub 2019 Apr 13. Eur J Cancer. 2019. PMID: 30991262 Free PMC article. Clinical Trial.
Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer.
Hill EJ, Roberts C, Franklin JM, Enescu M, West N, MacGregor TP, Chu KY, Boyle L, Blesing C, Wang LM, Mukherjee S, Anderson EM, Brown G, Dutton S, Love SB, Schnabel JA, Quirke P, Muschel R, McKenna WG, Partridge M, Sharma RA. Hill EJ, et al. Among authors: mckenna wg. Clin Cancer Res. 2016 Apr 15;22(8):1922-31. doi: 10.1158/1078-0432.CCR-15-1489. Epub 2016 Feb 9. Clin Cancer Res. 2016. PMID: 26861457 Free PMC article. Clinical Trial.
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia.
Ashton TM, Fokas E, Kunz-Schughart LA, Folkes LK, Anbalagan S, Huether M, Kelly CJ, Pirovano G, Buffa FM, Hammond EM, Stratford M, Muschel RJ, Higgins GS, McKenna WG. Ashton TM, et al. Among authors: mckenna wg. Nat Commun. 2016 Jul 25;7:12308. doi: 10.1038/ncomms12308. Nat Commun. 2016. PMID: 27453292 Free PMC article.
151 results