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Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.
Skwarski M, McGowan DR, Belcher E, Di Chiara F, Stavroulias D, McCole M, Derham JL, Chu KY, Teoh E, Chauhan J, O'Reilly D, Harris BHL, Macklin PS, Bull JA, Green M, Rodriguez-Berriguete G, Prevo R, Folkes LK, Campo L, Ferencz P, Croal PL, Flight H, Qi C, Holmes J, O'Connor JPB, Gleeson FV, McKenna WG, Harris AL, Bulte D, Buffa FM, Macpherson RE, Higgins GS. Skwarski M, et al. Among authors: chauhan j. Clin Cancer Res. 2021 May 1;27(9):2459-2469. doi: 10.1158/1078-0432.CCR-20-4128. Epub 2021 Feb 17. Clin Cancer Res. 2021. PMID: 33597271 Free PMC article.
The MITF regulatory network in melanoma.
Chauhan JS, Hölzel M, Lambert JP, Buffa FM, Goding CR. Chauhan JS, et al. Pigment Cell Melanoma Res. 2022 Sep;35(5):517-533. doi: 10.1111/pcmr.13053. Epub 2022 Jul 9. Pigment Cell Melanoma Res. 2022. PMID: 35771179 Free PMC article.
MITF controls the TCA cycle to modulate the melanoma hypoxia response.
Louphrasitthiphol P, Ledaki I, Chauhan J, Falletta P, Siddaway R, Buffa FM, Mole DR, Soga T, Goding CR. Louphrasitthiphol P, et al. Among authors: chauhan j. Pigment Cell Melanoma Res. 2019 Nov;32(6):792-808. doi: 10.1111/pcmr.12802. Epub 2019 Jul 8. Pigment Cell Melanoma Res. 2019. PMID: 31207090 Free PMC article.
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, Lu X, Tüting T, Middleton M, Buffa FM, Willis AE, Pavitt G, Ronai ZA, Sauka-Spengler T, Hölzel M, Goding CR. Falletta P, et al. Among authors: chauhan j. Genes Dev. 2017 Jan 1;31(1):18-33. doi: 10.1101/gad.290940.116. Epub 2017 Jan 17. Genes Dev. 2017. PMID: 28096186 Free PMC article.
RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M, O'Neill E. Papaspyropoulos A, et al. Among authors: chauhan j. Nat Commun. 2018 Jan 30;9(1):424. doi: 10.1038/s41467-017-02786-5. Nat Commun. 2018. PMID: 29382819 Free PMC article.
TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors.
Oliveira ÉA, Chauhan J, Silva JRD, Carvalho LADC, Dias D, Carvalho DG, Watanabe LRM, Rebecca VW, Mills G, Lu Y, da Silva ASF, Consolaro MEL, Herlyn M, Possik PA, Goding CR, Maria-Engler SS. Oliveira ÉA, et al. Among authors: chauhan j. Pharmacol Res. 2021 Nov;173:105911. doi: 10.1016/j.phrs.2021.105911. Epub 2021 Sep 22. Pharmacol Res. 2021. PMID: 34560251 Free PMC article.
TBX2 controls a proproliferative gene expression program in melanoma.
Lu S, Louphrasitthiphol P, Goradia N, Lambert JP, Schmidt J, Chauhan J, Rughani MG, Larue L, Wilmanns M, Goding CR. Lu S, et al. Among authors: chauhan j. Genes Dev. 2021 Dec 1;35(23-24):1657-1677. doi: 10.1101/gad.348746.121. Epub 2021 Nov 24. Genes Dev. 2021. PMID: 34819350 Free PMC article.
227 results