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A 2-pyridone amide inhibitor of transcriptional activity in Chlamydia trachomatis.
Núñez-Otero C, Bahnan W, Vielfort K, Silver J, Singh P, Elbir H, Almqvist F, Bergström S, Gylfe Å. Núñez-Otero C, et al. Antimicrob Agents Chemother. 2023 May 1;95(5):e01826-20. doi: 10.1128/AAC.01826-20. Epub 2021 Feb 16. Antimicrob Agents Chemother. 2023. PMID: 33593835 Free PMC article.
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.
Good JA, Silver J, Núñez-Otero C, Bahnan W, Krishnan KS, Salin O, Engström P, Svensson R, Artursson P, Gylfe Å, Bergström S, Almqvist F. Good JA, et al. Among authors: nunez otero c. J Med Chem. 2016 Mar 10;59(5):2094-108. doi: 10.1021/acs.jmedchem.5b01759. Epub 2016 Feb 22. J Med Chem. 2016. PMID: 26849778
N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF.
Mojica SA, Salin O, Bastidas RJ, Sunduru N, Hedenström M, Andersson CD, Núñez-Otero C, Engström P, Valdivia RH, Elofsson M, Gylfe Å. Mojica SA, et al. Among authors: nunez otero c. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00716-17. doi: 10.1128/AAC.00716-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28784680 Free PMC article.
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.
Kulén M, Núñez-Otero C, Cairns AG, Silver J, Lindgren AEG, Wede E, Singh P, Vielfort K, Bahnan W, Good JAD, Svensson R, Bergström S, Gylfe Å, Almqvist F. Kulén M, et al. Among authors: nunez otero c. Medchemcomm. 2019 Oct 17;10(11):1966-1987. doi: 10.1039/c9md00405j. eCollection 2019 Nov 1. Medchemcomm. 2019. PMID: 32206238 Free PMC article.