Wicht KJ - Search Results

1

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

Le Manach C, Dam J, Woodland JG, Kaur G, Khonde LP, Brunschwig C, Njoroge M, Wicht KJ, Horatscheck A, Paquet T, Boyle GA, Gibhard L, Taylor D, Lawrence N, Yeo T, Mok S, Eastman RT, Dorjsuren D, Talley DC, Guo H, Simeonov A, Reader J, van der Watt M, Erlank E, Venter N, Zawada JW, Aswat A, Nardini L, Coetzer TL, Lauterbach SB, Bezuidenhout BC, Theron A, Mancama D, Koekemoer LL, Birkholtz LM, Wittlin S, Delves M, Ottilie S, Winzeler EA, von Geldern TW, Smith D, Fidock DA, Street LJ, Basarab GS, Duffy J, Chibale K. Le Manach C, et al. Among authors: wicht kj. J Med Chem. 2021 Feb 25;64(4):2291-2309. doi: 10.1021/acs.jmedchem.1c00034. Epub 2021 Feb 12. J Med Chem. 2021. PMID: 33573376

2

In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles.

Joshi MC, Wicht KJ, Taylor D, Hunter R, Smith PJ, Egan TJ. Joshi MC, et al. Among authors: wicht kj. Eur J Med Chem. 2013 Nov;69:338-47. doi: 10.1016/j.ejmech.2013.08.046. Epub 2013 Sep 12. Eur J Med Chem. 2013. PMID: 24077524

3

Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11.

Wang N, Wicht KJ, Imai K, Wang MQ, Anh Ngoc T, Kiguchi R, Kaiser M, Egan TJ, Inokuchi T. Wang N, et al. Among authors: wicht kj. Bioorg Med Chem. 2014 May 1;22(9):2629-42. doi: 10.1016/j.bmc.2014.03.030. Epub 2014 Mar 26. Bioorg Med Chem. 2014. PMID: 24721829

4

Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.

Raj R, Mehra V, Gut J, Rosenthal PJ, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V. Raj R, et al. Among authors: wicht kj. Eur J Med Chem. 2014 Sep 12;84:425-32. doi: 10.1016/j.ejmech.2014.07.048. Epub 2014 Jul 15. Eur J Med Chem. 2014. PMID: 25038484

5

Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains.

Chugh M, Scheurer C, Sax S, Bilsland E, van Schalkwyk DA, Wicht KJ, Hofmann N, Sharma A, Bashyam S, Singh S, Oliver SG, Egan TJ, Malhotra P, Sutherland CJ, Beck HP, Wittlin S, Spangenberg T, Ding XC. Chugh M, et al. Among authors: wicht kj. Antimicrob Agents Chemother. 2015 Feb;59(2):1110-8. doi: 10.1128/AAC.03265-14. Epub 2014 Dec 8. Antimicrob Agents Chemother. 2015. PMID: 25487796 Free PMC article.

6

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.

Wicht KJ, Combrinck JM, Smith PJ, Egan TJ. Wicht KJ, et al. Bioorg Med Chem. 2015 Aug 15;23(16):5210-7. doi: 10.1016/j.bmc.2014.12.020. Epub 2014 Dec 20. Bioorg Med Chem. 2015. PMID: 25573118 Free PMC article.

7

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.

Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A. Figueiras M, et al. Among authors: wicht kj. Bioorg Med Chem. 2015 Apr 1;23(7):1530-9. doi: 10.1016/j.bmc.2015.02.007. Epub 2015 Feb 13. Bioorg Med Chem. 2015. PMID: 25725608

8

Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.

Ongarora DS, Strydom N, Wicht K, Njoroge M, Wiesner L, Egan TJ, Wittlin S, Jurva U, Masimirembwa CM, Chibale K. Ongarora DS, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5419-32. doi: 10.1016/j.bmc.2015.07.051. Epub 2015 Jul 30. Bioorg Med Chem. 2015. PMID: 26264839

9

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.

Wicht KJ, Combrinck JM, Smith PJ, Hunter R, Egan TJ. Wicht KJ, et al. J Med Chem. 2016 Jul 14;59(13):6512-30. doi: 10.1021/acs.jmedchem.6b00719. Epub 2016 Jun 24. J Med Chem. 2016. PMID: 27299916 Free PMC article.

10

Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.

Wicht KJ, Combrinck JM, Smith PJ, Hunter R, Egan TJ. Wicht KJ, et al. ACS Med Chem Lett. 2017 Jan 24;8(2):201-205. doi: 10.1021/acsmedchemlett.6b00416. eCollection 2017 Feb 9. ACS Med Chem Lett. 2017. PMID: 28197312 Free PMC article.

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