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Discovery of Novel Nonpeptidic PAR2 Ligands.
Klösel I, Schmidt MF, Kaindl J, Hübner H, Weikert D, Gmeiner P. Klösel I, et al. Among authors: schmidt mf. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. doi: 10.1021/acsmedchemlett.0c00154. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551018 Free PMC article.
Fluorescent ligands for dopamine D2/D3 receptors.
Allikalt A, Purkayastha N, Flad K, Schmidt MF, Tabor A, Gmeiner P, Hübner H, Weikert D. Allikalt A, et al. Among authors: schmidt mf. Sci Rep. 2020 Dec 14;10(1):21842. doi: 10.1038/s41598-020-78827-9. Sci Rep. 2020. PMID: 33318558 Free PMC article.
N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants.
Konieczny A, Conrad M, Ertl FJ, Gleixner J, Gattor AO, Grätz L, Schmidt MF, Neu E, Horn AHC, Wifling D, Gmeiner P, Clark T, Sticht H, Keller M. Konieczny A, et al. Among authors: schmidt mf. J Med Chem. 2021 Nov 25;64(22):16746-16769. doi: 10.1021/acs.jmedchem.1c01574. Epub 2021 Nov 8. J Med Chem. 2021. PMID: 34748345
Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.
Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P. Fink EA, et al. Among authors: schmidt mf. Science. 2022 Sep 30;377(6614):eabn7065. doi: 10.1126/science.abn7065. Epub 2022 Sep 30. Science. 2022. PMID: 36173843 Free PMC article.
Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt MF, Maul L, Pani B, Bahriz SM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch M, Kobilka BK. Casiraghi M, et al. Among authors: schmidt mf. bioRxiv [Preprint]. 2024 Apr 12:2024.03.28.587240. doi: 10.1101/2024.03.28.587240. bioRxiv. 2024. PMID: 38586060 Free PMC article. Preprint.
226 results