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Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).
Wagner CE, Jurutka PW, Marshall PA, Groy TL, van der Vaart A, Ziller JW, Furmick JK, Graeber ME, Matro E, Miguel BV, Tran IT, Kwon J, Tedeschi JN, Moosavi S, Danishyar A, Philp JS, Khamees RO, Jackson JN, Grupe DK, Badshah SL, Hart JW. Wagner CE, et al. J Med Chem. 2009 Oct 8;52(19):5950-66. doi: 10.1021/jm900496b. J Med Chem. 2009. PMID: 19791803 Free PMC article.
Modeling, synthesis and biological evaluation of potential retinoid X receptor-selective agonists: novel halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).
Furmick JK, Kaneko I, Walsh AN, Yang J, Bhogal JS, Gray GM, Baso JC, Browder DO, Prentice JL, Montano LA, Huynh CC, Marcus LM, Tsosie DG, Kwon JS, Quezada A, Reyes NM, Lemming B, Saini P, van der Vaart A, Groy TL, Marshall PA, Jurutka PW, Wagner CE. Furmick JK, et al. Among authors: wagner ce. ChemMedChem. 2012 Sep;7(9):1551-66. doi: 10.1002/cmdc.201200319. ChemMedChem. 2012. PMID: 22927238 Free PMC article.
Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254).
Jurutka PW, Kaneko I, Yang J, Bhogal JS, Swierski JC, Tabacaru CR, Montano LA, Huynh CC, Jama RA, Mahelona RD, Sarnowski JT, Marcus LM, Quezada A, Lemming B, Tedesco MA, Fischer AJ, Mohamed SA, Ziller JW, Ma N, Gray GM, van der Vaart A, Marshall PA, Wagner CE. Jurutka PW, et al. Among authors: wagner ce. J Med Chem. 2013 Nov 14;56(21):8432-54. doi: 10.1021/jm4008517. Epub 2013 Nov 1. J Med Chem. 2013. PMID: 24180745 Free PMC article.
Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles.
Marshall PA, Jurutka PW, Wagner CE, van der Vaart A, Kaneko I, Chavez PI, Ma N, Bhogal JS, Shahani P, Swierski JC, MacNeill M. Marshall PA, et al. Among authors: wagner ce. Pharmacol Res Perspect. 2015 Mar;3(2):e00122. doi: 10.1002/prp2.122. Epub 2015 Mar 16. Pharmacol Res Perspect. 2015. PMID: 26038698 Free PMC article.
Distinct functional modes of SUMOylation for retinoid X receptor alpha.
Lee WP, Jena S, Rodriguez EP, O'Donovan SP, Wagner C, Jurutka PW, Thompson PD. Lee WP, et al. Biochem Biophys Res Commun. 2015 Aug 14;464(1):195-200. doi: 10.1016/j.bbrc.2015.06.115. Epub 2015 Jun 23. Biochem Biophys Res Commun. 2015. PMID: 26116533
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN).
Heck MC, Wagner CE, Shahani PH, MacNeill M, Grozic A, Darwaiz T, Shimabuku M, Deans DG, Robinson NM, Salama SH, Ziller JW, Ma N, van der Vaart A, Marshall PA, Jurutka PW. Heck MC, et al. Among authors: wagner ce. J Med Chem. 2016 Oct 13;59(19):8924-8940. doi: 10.1021/acs.jmedchem.6b00812. Epub 2016 Sep 19. J Med Chem. 2016. PMID: 27592633
EDITORIAL (Thematic Issue : Rexinoids).
Wagner CE, Marshall PA, Jurutka PW. Wagner CE, et al. Curr Top Med Chem. 2017;17(6):629-630. doi: 10.2174/156802661706170111200835. Curr Top Med Chem. 2017. PMID: 28117026 No abstract available.
131 results