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An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo.
Keuters MH, Keksa-Goldsteine V, Dhungana H, Huuskonen MT, Pomeshchik Y, Savchenko E, Korhonen PK, Singh Y, Wojciechowski S, Lehtonen Š, Kanninen KM, Malm T, Sirviö J, Muona A, Koistinaho M, Goldsteins G, Koistinaho J. Keuters MH, et al. Among authors: keksa goldsteine v. Sci Rep. 2021 Feb 10;11(1):3518. doi: 10.1038/s41598-021-81741-3. Sci Rep. 2021. PMID: 33568697 Free PMC article.
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy.
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. Huuskonen MT, et al. Among authors: keksa goldsteine v. Sci Rep. 2016 Sep 14;6:33176. doi: 10.1038/srep33176. Sci Rep. 2016. PMID: 27624652 Free PMC article.
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
Liddell JR, Lehtonen S, Duncan C, Keksa-Goldsteine V, Levonen AL, Goldsteins G, Malm T, White AR, Koistinaho J, Kanninen KM. Liddell JR, et al. Among authors: keksa goldsteine v. J Neuroinflammation. 2016 Feb 26;13:49. doi: 10.1186/s12974-016-0515-9. J Neuroinflammation. 2016. PMID: 26920699 Free PMC article.
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models.
Lehtonen Š, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G. Lehtonen Š, et al. Among authors: keksa goldsteine v. Antioxid Redox Signal. 2016 Sep 10;25(8):485-97. doi: 10.1089/ars.2015.6402. Epub 2016 Jun 15. Antioxid Redox Signal. 2016. PMID: 27139804 Free article.
19 results