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The Infantile Leukoencephalopathy-Associated Mutation of C11ORF73/HIKESHI Proteins Generates de novo Interactive Activity with Filamin A, Inhibiting Oligodendroglial Cell Morphological Differentiation.
Hattori K, Tago K, Memezawa S, Ochiai A, Sawaguchi S, Kato Y, Sato T, Tomizuka K, Ooizumi H, Ohbuchi K, Mizoguchi K, Miyamoto Y, Yamauchi J. Hattori K, et al. Among authors: tomizuka k. Medicines (Basel). 2021 Feb 1;8(2):9. doi: 10.3390/medicines8020009. Medicines (Basel). 2021. PMID: 33535532 Free PMC article.
Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling.
Kazuki Y, Uno N, Abe S, Kajitani N, Kazuki K, Yakura Y, Sawada C, Takata S, Sugawara M, Nagashima Y, Okada A, Hiratsuka M, Osaki M, Ferrari G, Tedesco FS, Nishikawa S, Fukumoto K, Takayanagi SI, Kunisato A, Kaneko S, Oshimura M, Tomizuka K. Kazuki Y, et al. Among authors: tomizuka k. Mol Ther Nucleic Acids. 2020 Dec 19;23:629-639. doi: 10.1016/j.omtn.2020.12.012. eCollection 2021 Mar 5. Mol Ther Nucleic Acids. 2020. PMID: 33552683 Free PMC article.
A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells.
Kakeda M, Nagata K, Osawa K, Matsuno H, Hiratsuka M, Sano A, Okazaki A, Shitara S, Nishikawa S, Masuya A, Hata T, Wako S, Osaki M, Kazuki Y, Oshimura M, Tomizuka K. Kakeda M, et al. Among authors: tomizuka k. Biochem Biophys Res Commun. 2011 Nov 25;415(3):439-44. doi: 10.1016/j.bbrc.2011.10.088. Epub 2011 Oct 22. Biochem Biophys Res Commun. 2011. PMID: 22051050
Panel of human cell lines with human/mouse artificial chromosomes.
Uno N, Takata S, Komoto S, Miyamoto H, Nakayama Y, Osaki M, Mayuzumi R, Miyazaki N, Hando C, Abe S, Sakuma T, Yamamoto T, Suzuki T, Nakajima Y, Oshimura M, Tomizuka K, Kazuki Y. Uno N, et al. Among authors: tomizuka k. Sci Rep. 2022 Feb 22;12(1):3009. doi: 10.1038/s41598-022-06814-3. Sci Rep. 2022. PMID: 35194085 Free PMC article.
The use of chromosome-based vectors for animal transgenesis.
Kuroiwa Y, Yoshida H, Ohshima T, Shinohara T, Ohguma A, Kazuki Y, Oshimura M, Ishida I, Tomizuka K. Kuroiwa Y, et al. Among authors: tomizuka k. Gene Ther. 2002 Jun;9(11):708-12. doi: 10.1038/sj.gt.3301754. Gene Ther. 2002. PMID: 12032693
Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.
Kazuki Y, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y, Tsukazaki Y, Senda N, Kawakami H, Ohtsuki S, Abe S, Takiguchi M, Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K, Tomizuka K, Oshimura M. Kazuki Y, et al. Among authors: tomizuka k. Hum Mol Genet. 2013 Feb 1;22(3):578-92. doi: 10.1093/hmg/dds468. Epub 2012 Nov 2. Hum Mol Genet. 2013. PMID: 23125282
Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci.
Satofuka H, Abe S, Moriwaki T, Okada A, Kazuki K, Tanaka H, Yamazaki K, Hichiwa G, Morimoto K, Takayama H, Nakayama Y, Hatano S, Yada Y, Murakami Y, Baba Y, Oshimura M, Tomizuka K, Kazuki Y. Satofuka H, et al. Among authors: tomizuka k. Nat Commun. 2022 Apr 5;13(1):1841. doi: 10.1038/s41467-022-29421-2. Nat Commun. 2022. PMID: 35383174 Free PMC article.
86 results