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Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.
Zhang H, Hanson A, de Almeida TS, Emfinger C, McClenaghan C, Harter T, Yan Z, Cooper PE, Brown GS, Arakel EC, Mecham RP, Kovacs A, Halabi CM, Schwappach B, Remedi MS, Nichols CG. Zhang H, et al. Among authors: mecham rp. JCI Insight. 2021 Mar 8;6(5):e145934. doi: 10.1172/jci.insight.145934. JCI Insight. 2021. PMID: 33529173 Free PMC article.
Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.
Li A, Knutsen RH, Zhang H, Osei-Owusu P, Moreno-Dominguez A, Harter TM, Uchida K, Remedi MS, Dietrich HH, Bernal-Mizrachi C, Blumer KJ, Mecham RP, Koster JC, Nichols CG. Li A, et al. Among authors: mecham rp. J Am Heart Assoc. 2013 Aug 23;2(4):e000365. doi: 10.1161/JAHA.113.000365. J Am Heart Assoc. 2013. PMID: 23974906 Free PMC article.
Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.
Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML. Igoucheva O, et al. Among authors: mecham rp. J Biol Chem. 2015 Aug 28;290(35):21443-59. doi: 10.1074/jbc.M115.640425. Epub 2015 Jul 15. J Biol Chem. 2015. PMID: 26178373 Free PMC article.
Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.
Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D; Brigham Genomic Medicine; Mecham RP, Frank NY, Stitziel NO. Lee VS, et al. Among authors: mecham rp. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8759-64. doi: 10.1073/pnas.1601442113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432961 Free PMC article.
Elastin purification and solubilization.
Halabi CM, Mecham RP. Halabi CM, et al. Among authors: mecham rp. Methods Cell Biol. 2018;143:207-222. doi: 10.1016/bs.mcb.2017.08.012. Epub 2017 Nov 6. Methods Cell Biol. 2018. PMID: 29310779
Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis.
Kabir AU, Lee TJ, Pan H, Berry JC, Krchma K, Wu J, Liu F, Kang HK, Hinman K, Yang L, Hamilton S, Zhou Q, Veis DJ, Mecham RP, Wickline SA, Miller MJ, Choi K. Kabir AU, et al. Among authors: mecham rp. JCI Insight. 2018 Apr 19;3(8):e97349. doi: 10.1172/jci.insight.97349. eCollection 2018 Apr 19. JCI Insight. 2018. PMID: 29669933 Free PMC article.
Cardiovascular consequences of KATP overactivity in Cantu syndrome.
Huang Y, McClenaghan C, Harter TM, Hinman K, Halabi CM, Matkovich SJ, Zhang H, Brown GS, Mecham RP, England SK, Kovacs A, Remedi MS, Nichols CG. Huang Y, et al. Among authors: mecham rp. JCI Insight. 2018 Aug 9;3(15):e121153. doi: 10.1172/jci.insight.121153. eCollection 2018 Aug 9. JCI Insight. 2018. PMID: 30089727 Free PMC article.
319 results