Roush WR - Search Results

1

Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival.

Lo CH, Shay G, McGuire JJ, Li T, Shain KH, Choi JY, Fuerst R, Roush WR, Knapinska AM, Fields GB, Lynch CC. Lo CH, et al. Among authors: roush wr. Cancer Res. 2021 May 1;81(9):2415-2428. doi: 10.1158/0008-5472.CAN-20-2705. Epub 2021 Feb 1. Cancer Res. 2021. PMID: 33526510 Free PMC article.

2

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR. Roth J, et al. Among authors: roush wr. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7180-4. doi: 10.1016/j.bmcl.2011.09.077. Epub 2011 Sep 22. Bioorg Med Chem Lett. 2011. PMID: 22018790 Free PMC article.

3

Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

Choi JY, Plummer MS, Starr J, Desbonnet CR, Soutter H, Chang J, Miller JR, Dillman K, Miller AA, Roush WR. Choi JY, et al. Among authors: roush wr. J Med Chem. 2012 Jan 26;55(2):852-70. doi: 10.1021/jm201349f. Epub 2012 Jan 13. J Med Chem. 2012. PMID: 22243413 Free PMC article.

4

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.

Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bibian M, et al. Among authors: roush wr. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. Bioorg Med Chem Lett. 2013. PMID: 23787102 Free PMC article.

5

Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents.

Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Choi JY, et al. Among authors: roush wr. J Med Chem. 2013 Oct 10;56(19):7651-68. doi: 10.1021/jm401067s. Epub 2013 Sep 30. J Med Chem. 2013. PMID: 24079662 Free PMC article.

6

R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi.

Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. Choi JY, et al. Among authors: roush wr. ACS Med Chem Lett. 2014 Jan 22;5(4):434-9. doi: 10.1021/ml500010m. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900854 Free PMC article.

7

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D. Spicer TP, et al. Among authors: roush wr. J Med Chem. 2014 Nov 26;57(22):9598-611. doi: 10.1021/jm501284e. Epub 2014 Nov 11. J Med Chem. 2014. PMID: 25330343 Free PMC article.

8

Drug strategies targeting CYP51 in neglected tropical diseases.

Choi JY, Podust LM, Roush WR. Choi JY, et al. Among authors: roush wr. Chem Rev. 2014 Nov 26;114(22):11242-71. doi: 10.1021/cr5003134. Epub 2014 Oct 22. Chem Rev. 2014. PMID: 25337991 Free PMC article. Review. No abstract available.

9

Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase.

McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. McCall LI, et al. Among authors: roush wr. PLoS Negl Trop Dis. 2015 Mar 13;9(3):e0003588. doi: 10.1371/journal.pntd.0003588. eCollection 2015 Mar. PLoS Negl Trop Dis. 2015. PMID: 25768284 Free PMC article.

10

Structure Based Design of CYP51 Inhibitors.

Choi JY, Roush WR. Choi JY, et al. Among authors: roush wr. Curr Top Med Chem. 2017;17(1):30-39. doi: 10.2174/1568026616666160719164933. Curr Top Med Chem. 2017. PMID: 27449014 Review.

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