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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Vandyck K, Abdelnabi R, Gupta K, Jochmans D, Jekle A, Deval J, Misner D, Bardiot D, Foo CS, Liu C, Ren S, Beigelman L, Blatt LM, Boland S, Vangeel L, Dejonghe S, Chaltin P, Marchand A, Serebryany V, Stoycheva A, Chanda S, Symons JA, Raboisson P, Neyts J. Vandyck K, et al. Among authors: boland s. Biochem Biophys Res Commun. 2021 May 28;555:134-139. doi: 10.1016/j.bbrc.2021.03.096. Epub 2021 Mar 26. Biochem Biophys Res Commun. 2021. PMID: 33813272 Free PMC article.
An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.
Delbart F, Brams M, Gruss F, Noppen S, Peigneur S, Boland S, Chaltin P, Brandao-Neto J, von Delft F, Touw WG, Joosten RP, Liekens S, Tytgat J, Ulens C. Delbart F, et al. Among authors: boland s. J Biol Chem. 2018 Feb 16;293(7):2534-2545. doi: 10.1074/jbc.M117.815316. Epub 2017 Dec 13. J Biol Chem. 2018. PMID: 29237730 Free PMC article.
Design, synthesis and biological characterization of selective LIMK inhibitors.
Boland S, Bourin A, Alen J, Geraets J, Schroeders P, Castermans K, Kindt N, Boumans N, Panitti L, Vanormelingen J, Fransen S, Van de Velde S, Defert O. Boland S, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4005-10. doi: 10.1016/j.bmcl.2015.07.009. Epub 2015 Jul 10. Bioorg Med Chem Lett. 2015. PMID: 26233434
Rho kinase inhibitors: a patent review (2014 - 2016).
Defert O, Boland S. Defert O, et al. Among authors: boland s. Expert Opin Ther Pat. 2017 Apr;27(4):507-515. doi: 10.1080/13543776.2017.1272579. Epub 2017 Jan 16. Expert Opin Ther Pat. 2017. PMID: 28048944 Review.
Novel Roflumilast analogs as soft PDE4 inhibitors.
Boland S, Alen J, Bourin A, Castermans K, Boumans N, Panitti L, Vanormelingen J, Leysen D, Defert O. Boland S, et al. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4594-4597. doi: 10.1016/j.bmcl.2014.07.016. Epub 2014 Jul 12. Bioorg Med Chem Lett. 2014. PMID: 25149511
Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor.
Holvoet T, Devriese S, Castermans K, Boland S, Leysen D, Vandewynckel YP, Devisscher L, Van den Bossche L, Van Welden S, Dullaers M, Vandenbroucke RE, De Rycke R, Geboes K, Bourin A, Defert O, Hindryckx P, De Vos M, Laukens D. Holvoet T, et al. Among authors: boland s. Gastroenterology. 2017 Oct;153(4):1054-1067. doi: 10.1053/j.gastro.2017.06.013. Epub 2017 Jun 19. Gastroenterology. 2017. PMID: 28642198
163 results