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De novo design of modular and tunable protein biosensors.
Quijano-Rubio A, Yeh HW, Park J, Lee H, Langan RA, Boyken SE, Lajoie MJ, Cao L, Chow CM, Miranda MC, Wi J, Hong HJ, Stewart L, Oh BH, Baker D. Quijano-Rubio A, et al. Among authors: lajoie mj. Nature. 2021 Mar;591(7850):482-487. doi: 10.1038/s41586-021-03258-z. Epub 2021 Jan 27. Nature. 2021. PMID: 33503651 Free PMC article.
Multiplex pairwise assembly of array-derived DNA oligonucleotides.
Klein JC, Lajoie MJ, Schwartz JJ, Strauch EM, Nelson J, Baker D, Shendure J. Klein JC, et al. Among authors: lajoie mj. Nucleic Acids Res. 2016 Mar 18;44(5):e43. doi: 10.1093/nar/gkv1177. Epub 2015 Nov 8. Nucleic Acids Res. 2016. PMID: 26553805 Free PMC article.
Evolution of a designed protein assembly encapsulating its own RNA genome.
Butterfield GL, Lajoie MJ, Gustafson HH, Sellers DL, Nattermann U, Ellis D, Bale JB, Ke S, Lenz GH, Yehdego A, Ravichandran R, Pun SH, King NP, Baker D. Butterfield GL, et al. Among authors: lajoie mj. Nature. 2017 Dec 21;552(7685):415-420. doi: 10.1038/nature25157. Epub 2017 Dec 13. Nature. 2017. PMID: 29236688 Free PMC article.
De novo design of bioactive protein switches.
Langan RA, Boyken SE, Ng AH, Samson JA, Dods G, Westbrook AM, Nguyen TH, Lajoie MJ, Chen Z, Berger S, Mulligan VK, Dueber JE, Novak WRP, El-Samad H, Baker D. Langan RA, et al. Among authors: lajoie mj. Nature. 2019 Aug;572(7768):205-210. doi: 10.1038/s41586-019-1432-8. Epub 2019 Jul 24. Nature. 2019. PMID: 31341284 Free PMC article.
De novo design of modular and tunable allosteric biosensors.
Quijano-Rubio A, Yeh HW, Park J, Lee H, Langan RA, Boyken SE, Lajoie MJ, Cao L, Chow CM, Miranda MC, Wi J, Hong HJ, Stewart L, Oh BH, Baker D. Quijano-Rubio A, et al. Among authors: lajoie mj. bioRxiv [Preprint]. 2020 Jul 20:2020.07.18.206946. doi: 10.1101/2020.07.18.206946. bioRxiv. 2020. PMID: 32743576 Free PMC article. Updated. Preprint.
Designed protein logic to target cells with precise combinations of surface antigens.
Lajoie MJ, Boyken SE, Salter AI, Bruffey J, Rajan A, Langan RA, Olshefsky A, Muhunthan V, Bick MJ, Gewe M, Quijano-Rubio A, Johnson J, Lenz G, Nguyen A, Pun S, Correnti CE, Riddell SR, Baker D. Lajoie MJ, et al. Science. 2020 Sep 25;369(6511):1637-1643. doi: 10.1126/science.aba6527. Epub 2020 Aug 20. Science. 2020. PMID: 32820060 Free PMC article.
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.
Quijano-Rubio A, Bhuiyan AM, Yang H, Leung I, Bello E, Ali LR, Zhangxu K, Perkins J, Chun JH, Wang W, Lajoie MJ, Ravichandran R, Kuo YH, Dougan SK, Riddell SR, Spangler JB, Dougan M, Silva DA, Baker D. Quijano-Rubio A, et al. Among authors: lajoie mj. Nat Biotechnol. 2023 Apr;41(4):532-540. doi: 10.1038/s41587-022-01510-z. Epub 2022 Oct 31. Nat Biotechnol. 2023. PMID: 36316485 Free PMC article.
In vivo selection of synthetic nucleocapsids for tissue targeting.
Olshefsky A, Benasutti H, Sylvestre M, Butterfield GL, Rocklin GJ, Richardson C, Hicks DR, Lajoie MJ, Song K, Leaf E, Treichel C, Decarreau J, Ke S, Kher G, Carter L, Chamberlain JS, Baker D, King NP, Pun SH. Olshefsky A, et al. Among authors: lajoie mj. Proc Natl Acad Sci U S A. 2023 Nov 14;120(46):e2306129120. doi: 10.1073/pnas.2306129120. Epub 2023 Nov 8. Proc Natl Acad Sci U S A. 2023. PMID: 37939083 Free PMC article.
Biocontainment of genetically modified organisms by synthetic protein design.
Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville JE, Gregg CJ, Stoddard BL, Church GM. Mandell DJ, et al. Among authors: lajoie mj. Nature. 2015 Feb 5;518(7537):55-60. doi: 10.1038/nature14121. Epub 2015 Jan 21. Nature. 2015. PMID: 25607366 Free PMC article.
37 results