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Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission.
De Gregorio D, Popic J, Enns JP, Inserra A, Skalecka A, Markopoulos A, Posa L, Lopez-Canul M, Qianzi H, Lafferty CK, Britt JP, Comai S, Aguilar-Valles A, Sonenberg N, Gobbi G. De Gregorio D, et al. Among authors: aguilar valles a. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2020705118. doi: 10.1073/pnas.2020705118. Proc Natl Acad Sci U S A. 2021. PMID: 33495318 Free PMC article.
Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Gantois I, et al. Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15. Nat Med. 2017. PMID: 28504725 Free article.
Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.
Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G, Sonenberg N. Aguilar-Valles A, et al. Nat Commun. 2018 Jun 25;9(1):2459. doi: 10.1038/s41467-018-04883-5. Nat Commun. 2018. PMID: 29941989 Free PMC article.
Antidepressant actions of ketamine engage cell-specific translation via eIF4E.
Aguilar-Valles A, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Khlaifia A, Skaleka A, Lopez-Canul M, Torres-Berrio A, Bermudez S, Rurak GM, Simard S, Salmaso N, Gobbi G, Lacaille JC, Sonenberg N. Aguilar-Valles A, et al. Nature. 2021 Feb;590(7845):315-319. doi: 10.1038/s41586-020-03047-0. Epub 2020 Dec 16. Nature. 2021. PMID: 33328636
31 results