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Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies.
Tayari MM, Santos HGD, Kwon D, Bradley TJ, Thomassen A, Chen C, Dinh Y, Perez A, Zelent A, Morey L, Cimmino L, Shiekhattar R, Swords RT, Watts JM. Tayari MM, et al. Among authors: shiekhattar r. Clin Cancer Res. 2021 Apr 1;27(7):1893-1903. doi: 10.1158/1078-0432.CCR-20-4054. Epub 2021 Jan 25. Clin Cancer Res. 2021. PMID: 33495312 Free PMC article. Clinical Trial.
Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia.
Rocha-Viegas L, Villa R, Gutierrez A, Iriondo O, Shiekhattar R, Di Croce L. Rocha-Viegas L, et al. Among authors: shiekhattar r. Mol Cell Biol. 2014 Oct 1;34(19):3765-75. doi: 10.1128/MCB.00839-14. Epub 2014 Jul 28. Mol Cell Biol. 2014. PMID: 25071154 Free PMC article.
Integrator enforces the fidelity of transcriptional termination at protein-coding genes.
Dasilva LF, Blumenthal E, Beckedorff F, Cingaram PR, Gomes Dos Santos H, Edupuganti RR, Zhang A, Dokaneheifard S, Aoi Y, Yue J, Kirstein N, Tayari MM, Shilatifard A, Shiekhattar R. Dasilva LF, et al. Among authors: shiekhattar r. Sci Adv. 2021 Nov 5;7(45):eabe3393. doi: 10.1126/sciadv.abe3393. Epub 2021 Nov 3. Sci Adv. 2021. PMID: 34730992 Free PMC article.
The Integrator complex regulates microRNA abundance through RISC loading.
Kirstein N, Dokaneheifard S, Cingaram PR, Valencia MG, Beckedorff F, Gomes Dos Santos H, Blumenthal E, Tayari MM, Gaidosh GS, Shiekhattar R. Kirstein N, et al. Among authors: shiekhattar r. Sci Adv. 2023 Feb 10;9(6):eadf0597. doi: 10.1126/sciadv.adf0597. Epub 2023 Feb 10. Sci Adv. 2023. PMID: 36763664 Free PMC article.
TAF1 plays a critical role in AML1-ETO driven leukemogenesis.
Xu Y, Man N, Karl D, Martinez C, Liu F, Sun J, Martinez CJ, Martin GM, Beckedorff F, Lai F, Yue J, Roisman A, Greenblatt S, Duffort S, Wang L, Sun X, Figueroa M, Shiekhattar R, Nimer S. Xu Y, et al. Among authors: shiekhattar r. Nat Commun. 2019 Oct 29;10(1):4925. doi: 10.1038/s41467-019-12735-z. Nat Commun. 2019. PMID: 31664040 Free PMC article.
Targeted chemotherapy overcomes drug resistance in melanoma.
Yue J, Vendramin R, Liu F, Lopez O, Valencia MG, Gomes Dos Santos H, Gaidosh G, Beckedorff F, Blumenthal E, Speroni L, Nimer SD, Marine JC, Shiekhattar R. Yue J, et al. Among authors: shiekhattar r. Genes Dev. 2020 May 1;34(9-10):637-649. doi: 10.1101/gad.333864.119. Epub 2020 Apr 2. Genes Dev. 2020. PMID: 32241802 Free PMC article.
134 results