de Wilde G - Search Results

1

Metabolic Effects of Recurrent Genetic Aberrations in Multiple Myeloma.

Bloedjes TA, de Wilde G, Guikema JEJ. Bloedjes TA, et al. Among authors: de wilde g. Cancers (Basel). 2021 Jan 21;13(3):396. doi: 10.3390/cancers13030396. Cancers (Basel). 2021. PMID: 33494394 Free PMC article. Review.

2

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay.

Bahjat M, Bloedjes TA, van der Veen A, de Wilde G, Maas C, Guikema JEJ. Bahjat M, et al. Among authors: de wilde g. J Vis Exp. 2017 Jun 9;(124):55703. doi: 10.3791/55703. J Vis Exp. 2017. PMID: 28654064 Free PMC article.

3

The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors.

Bahjat M, de Wilde G, van Dam T, Maas C, Bloedjes T, Bende RJ, van Noesel CJM, Luijks DM, Eldering E, Kersten MJ, Guikema JEJ. Bahjat M, et al. Among authors: de wilde g. Cell Cycle. 2019 Sep;18(18):2307-2322. doi: 10.1080/15384101.2019.1646068. Epub 2019 Jul 26. Cell Cycle. 2019. PMID: 31349760 Free PMC article.

4

AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma.

Bloedjes TA, de Wilde G, Maas C, Eldering E, Bende RJ, van Noesel CJM, Pals ST, Spaargaren M, Guikema JEJ. Bloedjes TA, et al. Among authors: de wilde g. Blood Adv. 2020 Sep 8;4(17):4151-4164. doi: 10.1182/bloodadvances.2019001393. Blood Adv. 2020. PMID: 32898245 Free PMC article.

5

AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity.

Bloedjes TA, de Wilde G, Khan GH, Ashby TC, Shaughnessy JD, Zhan F, Houtkooper RH, Bende RJ, van Noesel CJM, Spaargaren M, Guikema JEJ. Bloedjes TA, et al. Among authors: de wilde g. Blood Adv. 2023 May 9;7(9):1697-1712. doi: 10.1182/bloodadvances.2022007383. Blood Adv. 2023. PMID: 36322819 Free PMC article.

6

Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector.

Pizzonero M, Akkari R, Bock X, Gosmini R, De Lemos E, Duthion B, Newsome G, Mai TT, Roques V, Jary H, Lefrancois JM, Cherel L, Quenehen V, Babel M, Merayo N, Bienvenu N, Mammoliti O, Coti G, Palisse A, Cowart M, Shrestha A, Greszler S, Van Der Plas S, Jansen K, Claes P, Jans M, Gees M, Borgonovi M, De Wilde G, Conrath K. Pizzonero M, et al. Among authors: de wilde g. J Med Chem. 2024 Apr 11;67(7):5216-5232. doi: 10.1021/acs.jmedchem.3c01790. Epub 2024 Mar 25. J Med Chem. 2024. PMID: 38527911 Free PMC article.

7

Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators.

de Wilde G, Gees M, Musch S, Verdonck K, Jans M, Wesse AS, Singh AK, Hwang TC, Christophe T, Pizzonero M, Van der Plas S, Desroy N, Cowart M, Stouten P, Nelles L, Conrath K. de Wilde G, et al. Front Pharmacol. 2019 May 9;10:514. doi: 10.3389/fphar.2019.00514. eCollection 2019. Front Pharmacol. 2019. PMID: 31143125 Free PMC article.

8

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.

Valdes AM, De Wilde G, Doherty SA, Lories RJ, Vaughn FL, Laslett LL, Maciewicz RA, Soni A, Hart DJ, Zhang W, Muir KR, Dennison EM, Wheeler M, Leaverton P, Cooper C, Spector TD, Cicuttini FM, Chapman V, Jones G, Arden NK, Doherty M. Valdes AM, et al. Among authors: de wilde g. Ann Rheum Dis. 2011 Sep;70(9):1556-61. doi: 10.1136/ard.2010.148122. Epub 2011 May 25. Ann Rheum Dis. 2011. PMID: 21616913 Free PMC article.

9

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).

Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Vermeulen L, et al. Among authors: de wilde g. EMBO J. 2003 Mar 17;22(6):1313-24. doi: 10.1093/emboj/cdg139. EMBO J. 2003. PMID: 12628924 Free PMC article.

10

Induction and repression of NF-kappa B-driven inflammatory genes.

Vanden Berghe W, De Bosscher K, Vermeulen L, De Wilde G, Haegeman G. Vanden Berghe W, et al. Among authors: de wilde g. Ernst Schering Res Found Workshop. 2002;(40):233-78. doi: 10.1007/978-3-662-04660-9_14. Ernst Schering Res Found Workshop. 2002. PMID: 12355719 Review. No abstract available.

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