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Rutin improves glutamate uptake and inhibits glutamate excitotoxicity in rat brain slices.
Ferreira RS, Teles-Souza J, Dos Santos Souza C, Pereira ÉPL, de Araújo FM, da Silva AB, Castro E Silva JH, Nonose Y, Núñez-Figueredo Y, de Assis AM, Souza DO, Costa MFD, Moreira JCF, Costa SL, da Silva VDA. Ferreira RS, et al. Among authors: costa mfd, costa sl. Mol Biol Rep. 2021 Feb;48(2):1475-1483. doi: 10.1007/s11033-021-06145-y. Epub 2021 Jan 25. Mol Biol Rep. 2021. PMID: 33492574
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Among authors: costa sl. Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19. Neuropharmacology. 2014. PMID: 24953828
Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.
Costa SL, Silva VD, Dos Santos Souza C, Santos CC, Paris I, Muñoz P, Segura-Aguilar J. Costa SL, et al. Neurotox Res. 2016 Jul;30(1):41-52. doi: 10.1007/s12640-016-9600-1. Epub 2016 Mar 7. Neurotox Res. 2016. PMID: 26951456 Review.
Aminochrome induces microglia and astrocyte activation.
Santos CC, Araújo FM, Ferreira RS, Silva VB, Silva JHC, Grangeiro MS, Soares ÉN, Pereira ÉPL, Souza CS, Costa SL, Segura-Aguilar J, Silva VDA. Santos CC, et al. Among authors: costa sl. Toxicol In Vitro. 2017 Aug;42:54-60. doi: 10.1016/j.tiv.2017.04.004. Epub 2017 Apr 6. Toxicol In Vitro. 2017. PMID: 28392416 Free article.
Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite).
Silva VDA, Cuevas C, Muñoz P, Villa M, Ahumada-Castro U, Huenchuguala S, Santos CCD, Araujo FM, Ferreira RS, Silva VBD, Silva JHCE, Soares ÉN, Velozo ES, Segura-Aguilar J, Costa SL. Silva VDA, et al. Among authors: costa sl. An Acad Bras Cienc. 2017 Jan-Mar;89(1):247-261. doi: 10.1590/0001-3765201720160477. An Acad Bras Cienc. 2017. PMID: 28423083 Free article.
Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.
de Araújo FM, Ferreira RS, Souza CS, Dos Santos CC, Rodrigues TLRS, E Silva JHC, Gasparotto J, Gelain DP, El-Bachá RS, D Costa MF, Fonseca JCM, Segura-Aguilar J, Costa SL, Silva VDA. de Araújo FM, et al. Among authors: costa sl. Neurotoxicology. 2018 May;66:98-106. doi: 10.1016/j.neuro.2018.03.009. Epub 2018 Mar 26. Neurotoxicology. 2018. PMID: 29588162 Free article.
JM-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson's disease.
Fonseca-Fonseca LA, Wong-Guerra M, Ramírez-Sánchez J, Montano-Peguero Y, Padrón Yaquis AS, Rodríguez AM, da Silva VDA, Costa SL, Pardo-Andreu GL, Núñez-Figueredo Y. Fonseca-Fonseca LA, et al. Among authors: costa sl. Neurosci Lett. 2019 Jan 18;690:29-35. doi: 10.1016/j.neulet.2018.10.008. Epub 2018 Oct 7. Neurosci Lett. 2019. PMID: 30304707
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: costa sl. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805
127 results