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Topical imiquimod yields systemic effects due to unintended oral uptake.
Grine L, Steeland S, Van Ryckeghem S, Ballegeer M, Lienenklaus S, Weiss S, Sanders NN, Vandenbroucke RE, Libert C. Grine L, et al. Among authors: lienenklaus s. Sci Rep. 2016 Jan 28;6:20134. doi: 10.1038/srep20134. Sci Rep. 2016. PMID: 26818707 Free PMC article.
Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.
De Beuckelaer A, Pollard C, Van Lint S, Roose K, Van Hoecke L, Naessens T, Udhayakumar VK, Smet M, Sanders N, Lienenklaus S, Saelens X, Weiss S, Vanham G, Grooten J, De Koker S. De Beuckelaer A, et al. Among authors: lienenklaus s. Mol Ther. 2016 Nov;24(11):2012-2020. doi: 10.1038/mt.2016.161. Epub 2016 Aug 10. Mol Ther. 2016. PMID: 27506450 Free PMC article.
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists.
De Vrieze J, Louage B, Deswarte K, Zhong Z, De Coen R, Van Herck S, Nuhn L, Kaas Frich C, Zelikin AN, Lienenklaus S, Sanders NN, Lambrecht BN, David SA, De Geest BG. De Vrieze J, et al. Among authors: lienenklaus s. Angew Chem Int Ed Engl. 2019 Oct 21;58(43):15390-15395. doi: 10.1002/anie.201905687. Epub 2019 Sep 12. Angew Chem Int Ed Engl. 2019. PMID: 31397948
Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles.
Wang B, Van Herck S, Chen Y, Bai X, Zhong Z, Deswarte K, Lambrecht BN, Sanders NN, Lienenklaus S, Scheeren HW, David SA, Kiessling F, Lammers T, De Geest BG, Shi Y. Wang B, et al. Among authors: lienenklaus s. J Am Chem Soc. 2020 Jul 15;142(28):12133-12139. doi: 10.1021/jacs.0c01928. Epub 2020 Jun 30. J Am Chem Soc. 2020. PMID: 32524819 Free PMC article.
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.
Jangra S, De Vrieze J, Choi A, Rathnasinghe R, Laghlali G, Uvyn A, Van Herck S, Nuhn L, Deswarte K, Zhong Z, Sanders N, Lienenklaus S, David S, Strohmeier S, Amanat F, Krammer F, Hammad H, Lambrecht BN, Coughlan L, García-Sastre A, De Geest BG, Schotsaert M. Jangra S, et al. Among authors: lienenklaus s. bioRxiv [Preprint]. 2020 Oct 23:2020.10.23.344085. doi: 10.1101/2020.10.23.344085. bioRxiv. 2020. PMID: 33106810 Free PMC article. Updated. Preprint.
107 results