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Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines.
Nhu D, Duffy S, Avery VM, Hughes A, Baell JB. Nhu D, et al. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4496-8. doi: 10.1016/j.bmcl.2010.06.036. Epub 2010 Jun 10. Bioorg Med Chem Lett. 2010. PMID: 20584608
3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity.
Ban K, Duffy S, Khakham Y, Avery VM, Hughes A, Montagnat O, Katneni K, Ryan E, Baell JB. Ban K, et al. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6024-9. doi: 10.1016/j.bmcl.2010.08.065. Epub 2010 Aug 19. Bioorg Med Chem Lett. 2010. PMID: 20822904
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.
Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, Baell JB. Ferrins L, et al. Among authors: baell jb. Eur J Med Chem. 2013 Aug;66:450-65. doi: 10.1016/j.ejmech.2013.05.007. Epub 2013 May 16. Eur J Med Chem. 2013. PMID: 23831695
Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.
Dennis ML, Chhabra S, Wang ZC, Debono A, Dolezal O, Newman J, Pitcher NP, Rahmani R, Cleary B, Barlow N, Hattarki M, Graham B, Peat TS, Baell JB, Swarbrick JD. Dennis ML, et al. Among authors: baell jb. J Med Chem. 2014 Nov 26;57(22):9612-26. doi: 10.1021/jm501417f. Epub 2014 Nov 12. J Med Chem. 2014. PMID: 25357262
163 results