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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L. Boeynaems S, et al. Among authors: van damme p, van den bosch l. Mol Cell. 2017 Mar 16;65(6):1044-1055.e5. doi: 10.1016/j.molcel.2017.02.013. Mol Cell. 2017. PMID: 28306503 Free PMC article.
Phasing in on the cell cycle.
Boeynaems S, Tompa P, Van Den Bosch L. Boeynaems S, et al. Among authors: van den bosch l. Cell Div. 2018 Jan 25;13:1. doi: 10.1186/s13008-018-0034-4. eCollection 2018. Cell Div. 2018. PMID: 29416553 Free PMC article. Review.
Protein Phase Separation: A New Phase in Cell Biology.
Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. Boeynaems S, et al. Among authors: van den bosch l. Trends Cell Biol. 2018 Jun;28(6):420-435. doi: 10.1016/j.tcb.2018.02.004. Epub 2018 Mar 27. Trends Cell Biol. 2018. PMID: 29602697 Free PMC article. Review.
Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties.
Boeynaems S, Holehouse AS, Weinhardt V, Kovacs D, Van Lindt J, Larabell C, Van Den Bosch L, Das R, Tompa PS, Pappu RV, Gitler AD. Boeynaems S, et al. Among authors: van lindt j, van den bosch l. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7889-7898. doi: 10.1073/pnas.1821038116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926670 Free PMC article.
HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
Fazal R, Boeynaems S, Swijsen A, De Decker M, Fumagalli L, Moisse M, Vanneste J, Guo W, Boon R, Vercruysse T, Eggermont K, Swinnen B, Beckers J, Pakravan D, Vandoorne T, Vanden Berghe P, Verfaillie C, Van Den Bosch L, Van Damme P. Fazal R, et al. Among authors: van damme p, van den bosch l. EMBO J. 2021 Apr 1;40(7):e106177. doi: 10.15252/embj.2020106177. Epub 2021 Mar 10. EMBO J. 2021. PMID: 33694180 Free PMC article.
Liquid-Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation.
Pakravan D, Michiels E, Bratek-Skicki A, De Decker M, Van Lindt J, Alsteens D, Derclaye S, Van Damme P, Schymkowitz J, Rousseau F, Tompa P, Van Den Bosch L. Pakravan D, et al. Among authors: van lindt j, van damme p, van den bosch l. Biomolecules. 2021 Apr 8;11(4):548. doi: 10.3390/biom11040548. Biomolecules. 2021. PMID: 33917983 Free PMC article.
317 results