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Page 1
Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa.
Mehla J, Malloci G, Mansbach R, López CA, Tsivkovski R, Haynes K, Leus IV, Grindstaff SB, Cascella RH, D'Cunha N, Herndon L, Hengartner NW, Margiotta E, Atzori A, Vargiu AV, Manrique PD, Walker JK, Lomovskaya O, Ruggerone P, Gnanakaran S, Rybenkov VV, Zgurskaya HI. Mehla J, et al. Among authors: tsivkovski r. mBio. 2021 Jan 19;12(1):e02785-20. doi: 10.1128/mBio.02785-20. mBio. 2021. PMID: 33468691 Free PMC article.
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
Hecker SJ, Reddy KR, Totrov M, Hirst GC, Lomovskaya O, Griffith DC, King P, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Clifton MC, Atkins K, Raymond A, Potts KT, Abendroth J, Boyer SH, Loutit JS, Morgan EE, Durso S, Dudley MN. Hecker SJ, et al. Among authors: tsivkovski r. J Med Chem. 2015 May 14;58(9):3682-92. doi: 10.1021/acs.jmedchem.5b00127. Epub 2015 Mar 17. J Med Chem. 2015. PMID: 25782055
Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.
Nelson K, Hemarajata P, Sun D, Rubio-Aparicio D, Tsivkovski R, Yang S, Sebra R, Kasarskis A, Nguyen H, Hanson BM, Leopold S, Weinstock G, Lomovskaya O, Humphries RM. Nelson K, et al. Among authors: tsivkovski r. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00989-17. doi: 10.1128/AAC.00989-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28739787 Free PMC article.
Biochemical Activity of Vaborbactam.
Tsivkovski R, Lomovskaya O. Tsivkovski R, et al. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01935-19. doi: 10.1128/AAC.01935-19. Print 2020 Jan 27. Antimicrob Agents Chemother. 2020. PMID: 31712199 Free PMC article.
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.
Hecker SJ, Reddy KR, Lomovskaya O, Griffith DC, Rubio-Aparicio D, Nelson K, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Parkinson J, Totrov M, Boyer SH, Glinka TW, Pemberton OA, Chen Y, Dudley MN. Hecker SJ, et al. Among authors: tsivkovski r. J Med Chem. 2020 Jul 23;63(14):7491-7507. doi: 10.1021/acs.jmedchem.9b01976. Epub 2020 Apr 2. J Med Chem. 2020. PMID: 32150407
Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases.
Lomovskaya O, Tsivkovski R, Nelson K, Rubio-Aparicio D, Sun D, Totrov M, Dudley MN. Lomovskaya O, et al. Among authors: tsivkovski r. Antimicrob Agents Chemother. 2020 May 21;64(6):e00212-20. doi: 10.1128/AAC.00212-20. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32229489 Free PMC article.
Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Lomovskaya O, Nelson K, Rubio-Aparicio D, Tsivkovski R, Sun D, Dudley MN. Lomovskaya O, et al. Among authors: tsivkovski r. Antimicrob Agents Chemother. 2020 May 21;64(6):e00552-20. doi: 10.1128/AAC.00552-20. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32229498 Free PMC article.
18 results