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DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens.
Hellmeier J, Platzer R, Eklund AS, Schlichthaerle T, Karner A, Motsch V, Schneider MC, Kurz E, Bamieh V, Brameshuber M, Preiner J, Jungmann R, Stockinger H, Schütz GJ, Huppa JB, Sevcsik E. Hellmeier J, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2016857118. doi: 10.1073/pnas.2016857118. Proc Natl Acad Sci U S A. 2021. PMID: 33468643 Free PMC article.
CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer.
Menon AP, Villanueva H, Meraviglia-Crivelli D, van Santen HM, Hellmeier J, Zheleva A, Nonateli F, Peters T, Wachsmann TLA, Hernandez-Rueda M, Huppa JB, Schütz GJ, Sevcsik E, Moreno B, Pastor F. Menon AP, et al. Among authors: hellmeier j. Mol Ther Nucleic Acids. 2024 Apr 23;35(2):102198. doi: 10.1016/j.omtn.2024.102198. eCollection 2024 Jun 11. Mol Ther Nucleic Acids. 2024. PMID: 38745854 Free PMC article.
Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion.
Platzer R, Hellmeier J, Göhring J, Perez ID, Schatzlmaier P, Bodner C, Focke-Tejkl M, Schütz GJ, Sevcsik E, Stockinger H, Brameshuber M, Huppa JB. Platzer R, et al. Among authors: hellmeier j. EMBO Rep. 2023 Nov 6;24(11):e57842. doi: 10.15252/embr.202357842. Epub 2023 Sep 28. EMBO Rep. 2023. PMID: 37768718 Free PMC article.