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Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment.
Guo J, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E; DonorConnect; Plath K, Hotaling JM, Stukenborg JB, Clark AT, Cairns BR. Guo J, et al. Among authors: cairns br. Cell Stem Cell. 2021 Apr 1;28(4):764-778.e4. doi: 10.1016/j.stem.2020.12.004. Epub 2021 Jan 15. Cell Stem Cell. 2021. PMID: 33453151 Free PMC article.
Cigarette smoking significantly alters sperm DNA methylation patterns.
Jenkins TG, James ER, Alonso DF, Hoidal JR, Murphy PJ, Hotaling JM, Cairns BR, Carrell DT, Aston KI. Jenkins TG, et al. Among authors: cairns br. Andrology. 2017 Nov;5(6):1089-1099. doi: 10.1111/andr.12416. Epub 2017 Sep 26. Andrology. 2017. PMID: 28950428 Free PMC article.
The adult human testis transcriptional cell atlas.
Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, Guo Y, Takei Y, Yun J, Cai L, Kim R, Carrell DT, Goriely A, Hotaling JM, Cairns BR. Guo J, et al. Among authors: cairns br. Cell Res. 2018 Dec;28(12):1141-1157. doi: 10.1038/s41422-018-0099-2. Epub 2018 Oct 12. Cell Res. 2018. PMID: 30315278 Free PMC article.
The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty.
Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ; DonorConnect; Kim R, Tharmalingam M, Matilionyte G, Lindskog C, Carrell DT, Mitchell RT, Goriely A, Hotaling JM, Cairns BR. Guo J, et al. Among authors: cairns br. Cell Stem Cell. 2020 Feb 6;26(2):262-276.e4. doi: 10.1016/j.stem.2019.12.005. Epub 2020 Jan 9. Cell Stem Cell. 2020. PMID: 31928944 Free PMC article.
NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure.
Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR, Aston KI. Murphy PJ, et al. Among authors: cairns br. PLoS Genet. 2020 Jun 10;16(6):e1008756. doi: 10.1371/journal.pgen.1008756. eCollection 2020 Jun. PLoS Genet. 2020. PMID: 32520939 Free PMC article.
Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer.
Tharmalingam MD, Matilionyte G, Wallace WHB, Stukenborg JB, Jahnukainen K, Oliver E, Goriely A, Lane S, Guo J, Cairns B, Jorgensen A, Allen CM, Lopes F, Anderson RA, Spears N, Mitchell RT. Tharmalingam MD, et al. BMC Med. 2020 Dec 4;18(1):374. doi: 10.1186/s12916-020-01844-y. BMC Med. 2020. PMID: 33272271 Free PMC article.
p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.
Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR. Grow EJ, et al. Among authors: cairns br. Nat Genet. 2021 Aug;53(8):1207-1220. doi: 10.1038/s41588-021-00893-0. Epub 2021 Jul 15. Nat Genet. 2021. PMID: 34267371 Free PMC article.
139 results