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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Blümel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, Wölfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, Stühler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S. Marquardt V, et al. J Immunother Cancer. 2023 Jan;11(1):e005871. doi: 10.1136/jitc-2022-005871. J Immunother Cancer. 2023. PMID: 36639156 Free PMC article.
A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma.
Herrera-Rios D, Li G, Khan D, Tsiampali J, Nickel AC, Aretz P, Hewera M, Suwala AK, Jiang T, Steiger HJ, Kamp MA, Muhammad S, Hänggi D, Maciaczyk J, Zhang W, Kahlert UD. Herrera-Rios D, et al. Among authors: kahlert ud. Sci Rep. 2020 Oct 1;10(1):16218. doi: 10.1038/s41598-020-72480-y. Sci Rep. 2020. PMID: 33004830 Free PMC article.
Association between health insurance status and malignant glioma.
Fischer I, Mijderwijk HJ, Kahlert UD, Rapp M, Sabel M, Hänggi D, Steiger HJ, Forster MT, Kamp MA. Fischer I, et al. Among authors: kahlert ud. Neurooncol Pract. 2020 Jun 6;7(5):531-540. doi: 10.1093/nop/npaa030. eCollection 2020 Oct. Neurooncol Pract. 2020. PMID: 33014394 Free PMC article.
92 results