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Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution.
Schlein C, Fischer AW, Sass F, Worthmann A, Tödter K, Jaeckstein MY, Behrens J, Lynes MD, Kiebish MA, Narain NR, Bussberg V, Darkwah A, Jespersen NZ, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng YH, Heeren J, Scheja L. Schlein C, et al. Cell Rep. 2021 Jan 12;34(2):108624. doi: 10.1016/j.celrep.2020.108624. Cell Rep. 2021. PMID: 33440156 Free PMC article.
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. Lynes MD, et al. Among authors: schlein c. Nat Med. 2017 May;23(5):631-637. doi: 10.1038/nm.4297. Epub 2017 Mar 27. Nat Med. 2017. PMID: 28346411 Free PMC article.
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Bartelt A, et al. Among authors: schlein c. Nat Med. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400713 Free PMC article.
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation.
Fischer AW, Jaeckstein MY, Gottschling K, Heine M, Sass F, Mangels N, Schlein C, Worthmann A, Bruns OT, Yuan Y, Zhu H, Chen O, Ittrich H, Nilsson SK, Stefanicka P, Ukropec J, Balaz M, Dong H, Sun W, Reimer R, Scheja L, Heeren J. Fischer AW, et al. Among authors: schlein c. Cell Metab. 2021 Mar 2;33(3):547-564.e7. doi: 10.1016/j.cmet.2020.12.001. Epub 2020 Dec 22. Cell Metab. 2021. PMID: 33357458 Free article.
26 results