Scadden DT - Search Results

1

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.

Oki T, Mercier F, Kato H, Jung Y, McDonald TO, Spencer JA, Mazzola MC, van Gastel N, Lin CP, Michor F, Kitamura T, Scadden DT. Oki T, et al. Among authors: scadden dt. Nat Commun. 2021 Jan 11;12(1):245. doi: 10.1038/s41467-020-20491-8. Nat Commun. 2021. PMID: 33431855 Free PMC article.

2

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.

Sipkins DA, Wei X, Wu JW, Runnels JM, Côté D, Means TK, Luster AD, Scadden DT, Lin CP. Sipkins DA, et al. Among authors: scadden dt. Nature. 2005 Jun 16;435(7044):969-73. doi: 10.1038/nature03703. Nature. 2005. PMID: 15959517 Free PMC article.

3

The stem-cell niche as an entity of action.

Scadden DT. Scadden DT. Nature. 2006 Jun 29;441(7097):1075-9. doi: 10.1038/nature04957. Nature. 2006. PMID: 16810242 Review.

4

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Janzen V, et al. Among authors: scadden dt. Nature. 2006 Sep 28;443(7110):421-6. doi: 10.1038/nature05159. Epub 2006 Sep 6. Nature. 2006. PMID: 16957735

5

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.

Lo Celso C, Fleming HE, Wu JW, Zhao CX, Miake-Lye S, Fujisaki J, Côté D, Rowe DW, Lin CP, Scadden DT. Lo Celso C, et al. Among authors: scadden dt. Nature. 2009 Jan 1;457(7225):92-6. doi: 10.1038/nature07434. Epub 2008 Dec 3. Nature. 2009. PMID: 19052546 Free PMC article.

6

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.

Adams GB, Alley IR, Chung UI, Chabner KT, Jeanson NT, Lo Celso C, Marsters ES, Chen M, Weinstein LS, Lin CP, Kronenberg HM, Scadden DT. Adams GB, et al. Among authors: scadden dt. Nature. 2009 May 7;459(7243):103-7. doi: 10.1038/nature07859. Epub 2009 Mar 25. Nature. 2009. PMID: 19322176 Free PMC article.

7

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Raaijmakers MH, et al. Among authors: scadden dt, scadden eo. Nature. 2010 Apr 8;464(7290):852-7. doi: 10.1038/nature08851. Epub 2010 Mar 21. Nature. 2010. PMID: 20305640 Free PMC article.

8

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. Gurumurthy S, et al. Among authors: scadden dt. Nature. 2010 Dec 2;468(7324):659-63. doi: 10.1038/nature09572. Nature. 2010. PMID: 21124451 Free PMC article.

9

In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow.

Lo Celso C, Lin CP, Scadden DT. Lo Celso C, et al. Among authors: scadden dt. Nat Protoc. 2011 Jan;6(1):1-14. doi: 10.1038/nprot.2010.168. Epub 2010 Dec 9. Nat Protoc. 2011. PMID: 21212779 Free PMC article.

10

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.

Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP. Fujisaki J, et al. Among authors: scadden dt. Nature. 2011 Jun 8;474(7350):216-9. doi: 10.1038/nature10160. Nature. 2011. PMID: 21654805 Free PMC article.

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