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Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo.
Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF. Dominguez-Meijide A, et al. Among authors: lazaro df. Neurobiol Dis. 2021 Apr;151:105256. doi: 10.1016/j.nbd.2021.105256. Epub 2021 Jan 8. Neurobiol Dis. 2021. PMID: 33429042 Free article.
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M. Yin G, et al. Among authors: lazaro df. Neurobiol Dis. 2014 Oct;70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28. Neurobiol Dis. 2014. PMID: 24983211
Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF. Paiva I, et al. Among authors: lazaro df. Neurobiol Dis. 2018 Nov;119:121-135. doi: 10.1016/j.nbd.2018.08.001. Epub 2018 Aug 6. Neurobiol Dis. 2018. PMID: 30092270
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfó E, Ventura S. Pujols J, et al. Among authors: lazaro df. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486. doi: 10.1073/pnas.1804198115. Epub 2018 Sep 24. Proc Natl Acad Sci U S A. 2018. PMID: 30249646 Free PMC article.
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.
Masaracchia C, König A, Valiente-Gabioud AA, Peralta P, Favretto F, Strohäker T, Lázaro DF, Zweckstetter M, Fernandez CO, Outeiro TF. Masaracchia C, et al. Among authors: lazaro df. Biochim Biophys Acta Proteins Proteom. 2020 Jan;1868(1):140298. doi: 10.1016/j.bbapap.2019.140298. Epub 2019 Oct 30. Biochim Biophys Acta Proteins Proteom. 2020. PMID: 31676453
Synucleinopathies: Where we are and where we need to go.
Brás IC, Dominguez-Meijide A, Gerhardt E, Koss D, Lázaro DF, Santos PI, Vasili E, Xylaki M, Outeiro TF. Brás IC, et al. Among authors: lazaro df. J Neurochem. 2020 May;153(4):433-454. doi: 10.1111/jnc.14965. Epub 2020 Feb 19. J Neurochem. 2020. PMID: 31957016 Free article. Review.
35 results