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Targeting T-type/CaV3.2 channels for chronic pain.
Cai S, Gomez K, Moutal A, Khanna R. Cai S, et al. Among authors: khanna r. Transl Res. 2021 Aug;234:20-30. doi: 10.1016/j.trsl.2021.01.002. Epub 2021 Jan 7. Transl Res. 2021. PMID: 33422652 Free PMC article. Review.
The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.
Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, François-Moutal L, Khanna M, Khanna R. Wilson SM, et al. Among authors: khanna r, khanna m. Front Cell Neurosci. 2014 Jul 24;8:196. doi: 10.3389/fncel.2014.00196. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25104922 Free PMC article.
A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.
François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. François-Moutal L, et al. Among authors: khanna r, khanna m. Pain. 2015 Jul;156(7):1247-1264. doi: 10.1097/j.pain.0000000000000147. Pain. 2015. PMID: 25782368 Free PMC article.
CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.
Moutal A, Honnorat J, Massoma P, Désormeaux P, Bertrand C, Malleval C, Watrin C, Chounlamountri N, Mayeur ME, Besançon R, Naudet N, Magadoux L, Khanna R, Ducray F, Meyronet D, Thomasset N. Moutal A, et al. Among authors: khanna r. Cancer Res. 2015 Sep 1;75(17):3519-28. doi: 10.1158/0008-5472.CAN-14-0631. Epub 2015 Jun 29. Cancer Res. 2015. PMID: 26122847
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, Porreca F, Khanna R. Moutal A, et al. Among authors: khanna r, khanna m. Pain. 2016 Jul;157(7):1448-1463. doi: 10.1097/j.pain.0000000000000555. Pain. 2016. PMID: 26967696 Free PMC article.
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.
Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Moutal A, et al. Among authors: khanna r. Pain Rep. 2016 Jun;1(1):e565. doi: 10.1097/PR9.0000000000000565. Pain Rep. 2016. PMID: 27917413 Free PMC article.
2,043 results