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Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M. de la Paz Santangelo M, et al. Among authors: schnappinger d. J Biol Chem. 2011 Nov 18;286(46):40219-31. doi: 10.1074/jbc.M111.259440. Epub 2011 Sep 23. J Biol Chem. 2011. PMID: 21949126 Free PMC article.
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D, Finzel BC, Aldrich CC. Bockman MR, et al. Among authors: schnappinger d. J Med Chem. 2015 Sep 24;58(18):7349-7369. doi: 10.1021/acs.jmedchem.5b00719. Epub 2015 Sep 3. J Med Chem. 2015. PMID: 26299766 Free PMC article.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S. Xu W, et al. Among authors: schnappinger d. Antimicrob Agents Chemother. 2017 Nov 22;61(12):e01334-17. doi: 10.1128/AAC.01334-17. Print 2017 Dec. Antimicrob Agents Chemother. 2017. PMID: 28893793 Free PMC article.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, Dartois V, Schnappinger D. Tiwari D, et al. Among authors: schnappinger d. Sci Transl Med. 2018 Apr 25;10(438):eaal1803. doi: 10.1126/scitranslmed.aal1803. Sci Transl Med. 2018. PMID: 29695454 Free PMC article.
Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N, Olsen DB, Goodwin M, Sutphin M, Weiner DM, Via LE, Boshoff HIM, Barry CE 3rd. Oh S, et al. Among authors: schnappinger d. J Med Chem. 2018 Nov 21;61(22):9952-9965. doi: 10.1021/acs.jmedchem.8b00883. Epub 2018 Nov 5. J Med Chem. 2018. PMID: 30350998 Free PMC article.
Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.
Bockman MR, Engelhart CA, Cramer JD, Howe MD, Mishra NK, Zimmerman M, Larson P, Alvarez-Cabrera N, Park SW, Boshoff HIM, Bean JM, Young VG Jr, Ferguson DM, Dartois V, Jarrett JT, Schnappinger D, Aldrich CC. Bockman MR, et al. Among authors: schnappinger d. ACS Infect Dis. 2019 Apr 12;5(4):598-617. doi: 10.1021/acsinfecdis.8b00345. Epub 2019 Feb 4. ACS Infect Dis. 2019. PMID: 30652474 Free PMC article.
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.
Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, Scarry SM, Aubé J, Yang G, Ouerfelli O, Schnappinger D, Ioerger TR, Engelhart CA, McConnell JA, McAulay K, Fay A, Roubert C, Sacchettini J, Nathan C. Ballinger E, et al. Among authors: schnappinger d. Science. 2019 Feb 1;363(6426):eaau8959. doi: 10.1126/science.aau8959. Science. 2019. PMID: 30705156 Free PMC article.
133 results