Taylor D - Search Results

1

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.

Soares de Melo C, Singh V, Myrick A, Simelane SB, Taylor D, Brunschwig C, Lawrence N, Schnappinger D, Engelhart CA, Kumar A, Parish T, Su Q, Myers TG, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden PD, Buchanan KI, Bayliss T, Green SR, Ray PC, Wyatt PG, Basarab GS, Eyermann CJ, Chibale K, Ghorpade SR. Soares de Melo C, et al. Among authors: taylor d. J Med Chem. 2021 Jan 14;64(1):719-740. doi: 10.1021/acs.jmedchem.0c01727. Epub 2021 Jan 4. J Med Chem. 2021. PMID: 33395287 Free PMC article.

2

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Musonda CC, et al. Among authors: taylor d. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3901-5. doi: 10.1016/j.bmcl.2004.05.063. Bioorg Med Chem Lett. 2004. PMID: 15225694

3

Reversal of chloroquine resistance in Plasmodium falciparum by 9H-xanthene derivatives.

Wu CP, van Schalkwyk DA, Taylor D, Smith PJ, Chibale K. Wu CP, et al. Among authors: taylor d. Int J Antimicrob Agents. 2005 Aug;26(2):170-5. doi: 10.1016/j.ijantimicag.2005.04.018. Int J Antimicrob Agents. 2005. PMID: 16009536

4

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

Zishiri VK, Hunter R, Smith PJ, Taylor D, Summers R, Kirk K, Martin RE, Egan TJ. Zishiri VK, et al. Among authors: taylor d. Eur J Med Chem. 2011 May;46(5):1729-42. doi: 10.1016/j.ejmech.2011.02.026. Epub 2011 Feb 22. Eur J Med Chem. 2011. PMID: 21396749

5

Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.

Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Aminake MN, et al. Among authors: taylor d. Bioorg Med Chem. 2012 Sep 1;20(17):5277-89. doi: 10.1016/j.bmc.2012.06.038. Epub 2012 Jun 29. Bioorg Med Chem. 2012. PMID: 22858300

6

Synthesis, characterization, antiparasitic and cytotoxic evaluation of thioureas conjugated to polyamine scaffolds.

Stringer T, Taylor D, de Kock C, Guzgay H, Au A, An SH, Sanchez B, O'Connor R, Patel N, Land KM, Smith PJ, Hendricks DT, Egan TJ, Smith GS. Stringer T, et al. Among authors: taylor d. Eur J Med Chem. 2013 Nov;69:90-8. doi: 10.1016/j.ejmech.2013.08.004. Epub 2013 Aug 11. Eur J Med Chem. 2013. PMID: 24012713

7

In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles.

Joshi MC, Wicht KJ, Taylor D, Hunter R, Smith PJ, Egan TJ. Joshi MC, et al. Among authors: taylor d. Eur J Med Chem. 2013 Nov;69:338-47. doi: 10.1016/j.ejmech.2013.08.046. Epub 2013 Sep 12. Eur J Med Chem. 2013. PMID: 24077524

8

Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents.

Chellan P, Land KM, Shokar A, Au A, An SH, Taylor D, Smith PJ, Riedel T, Dyson PJ, Chibale K, Smith GS. Chellan P, et al. Among authors: taylor d. Dalton Trans. 2014 Jan 14;43(2):513-26. doi: 10.1039/c3dt52090k. Dalton Trans. 2014. PMID: 24121555 Free article.

9

2,4-Diaminothienopyrimidines as orally active antimalarial agents.

González Cabrera D, Le Manach C, Douelle F, Younis Y, Feng TS, Paquet T, Nchinda AT, Street LJ, Taylor D, de Kock C, Wiesner L, Duffy S, White KL, Zabiulla KM, Sambandan Y, Bashyam S, Waterson D, Witty MJ, Charman SA, Avery VM, Wittlin S, Chibale K. González Cabrera D, et al. Among authors: taylor d. J Med Chem. 2014 Feb 13;57(3):1014-22. doi: 10.1021/jm401760c. Epub 2014 Jan 28. J Med Chem. 2014. PMID: 24446664

10

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

Le Manach C, Gonzàlez Cabrera D, Douelle F, Nchinda AT, Younis Y, Taylor D, Wiesner L, White KL, Ryan E, March C, Duffy S, Avery VM, Waterson D, Witty MJ, Wittlin S, Charman SA, Street LJ, Chibale K. Le Manach C, et al. Among authors: taylor d. J Med Chem. 2014 Mar 27;57(6):2789-98. doi: 10.1021/jm500098s. Epub 2014 Mar 13. J Med Chem. 2014. PMID: 24568587

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