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Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics.
Huck V, Chen PC, Xu ER, Tischer A, Klemm U, Aponte-Santamaría C, Mess C, Obser T, Kutzki F, König G, Denis CV, Gräter F, Wilmanns M, Auton M, Schneider SW, Schneppenheim R, Hennig J, Brehm MA. Huck V, et al. Among authors: obser t. Thromb Haemost. 2022 Feb;122(2):226-239. doi: 10.1055/a-1344-4405. Epub 2021 Apr 14. Thromb Haemost. 2022. PMID: 33385180 Free PMC article.
von Willebrand factor directly interacts with DNA from neutrophil extracellular traps.
Grässle S, Huck V, Pappelbaum KI, Gorzelanny C, Aponte-Santamaría C, Baldauf C, Gräter F, Schneppenheim R, Obser T, Schneider SW. Grässle S, et al. Among authors: obser t. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1382-9. doi: 10.1161/ATVBAHA.113.303016. Epub 2014 May 1. Arterioscler Thromb Vasc Biol. 2014. PMID: 24790143
Mutual A domain interactions in the force sensing protein von Willebrand factor.
Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P. Posch S, et al. Among authors: obser t. J Struct Biol. 2017 Jan;197(1):57-64. doi: 10.1016/j.jsb.2016.04.012. Epub 2016 Apr 23. J Struct Biol. 2017. PMID: 27113902 Free article.
Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.
Xu ER, von Bülow S, Chen PC, Lenting PJ, Kolšek K, Aponte-Santamaría C, Simon B, Foot J, Obser T, Schneppenheim R, Gräter F, Denis CV, Wilmanns M, Hennig J. Xu ER, et al. Among authors: obser t. Blood. 2019 Jan 24;133(4):366-376. doi: 10.1182/blood-2018-04-843615. Epub 2018 Oct 10. Blood. 2019. PMID: 30305279 Free PMC article.
Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease.
Tischer A, Brehm MA, Machha VR, Moon-Tasson L, Benson LM, Nelton KJ, Leger RR, Obser T, Martinez-Vargas M, Whitten ST, Chen D, Pruthi RK, Bergen HR 3rd, Cruz MA, Schneppenheim R, Auton M. Tischer A, et al. Among authors: obser t. J Mol Biol. 2020 Jan 17;432(2):305-323. doi: 10.1016/j.jmb.2019.09.022. Epub 2019 Oct 17. J Mol Biol. 2020. PMID: 31628947 Free PMC article.
63 results