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siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O'Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O'Callaghan J. Cassidy PS, et al. Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33376757 Free PMC article.
Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.
Tam LC, Reina-Torres E, Sherwood JM, Cassidy PS, Crosbie DE, Lütjen-Drecoll E, Flügel-Koch C, Perkumas K, Humphries MM, Kiang AS, O'Callaghan J, Callanan JJ, Read AT, Ethier CR, O'Brien C, Lawrence M, Campbell M, Stamer WD, Overby DR, Humphries P. Tam LC, et al. Sci Rep. 2017 Jan 16;7:40717. doi: 10.1038/srep40717. Sci Rep. 2017. PMID: 28091584 Free PMC article.
Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.
Kelly RA, Perkumas KM, Campbell M, Farrar GJ, Stamer WD, Humphries P, O'Callaghan J, O'Brien CJ. Kelly RA, et al. Int J Mol Sci. 2021 Aug 31;22(17):9446. doi: 10.3390/ijms22179446. Int J Mol Sci. 2021. PMID: 34502356 Free PMC article.
The role of matricellular proteins in glaucoma.
Wallace DM, Murphy-Ullrich JE, Downs JC, O'Brien CJ. Wallace DM, et al. Matrix Biol. 2014 Jul;37:174-82. doi: 10.1016/j.matbio.2014.03.007. Epub 2014 Apr 12. Matrix Biol. 2014. PMID: 24727033 Free article. Review.
2,774 results