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siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O'Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O'Callaghan J. Cassidy PS, et al. Among authors: campbell m. Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33376757 Free PMC article.
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: campbell m. Hum Mol Genet. 2008 Jul 15;17(14):2084-100. doi: 10.1093/hmg/ddn107. Epub 2008 Apr 1. Hum Mol Genet. 2008. PMID: 18385099
RNAi-mediated reversible opening of the blood-brain barrier.
Campbell M, Kiang AS, Kenna PF, Kerskens C, Blau C, O'Dwyer L, Tivnan A, Kelly JA, Brankin B, Farrar GJ, Humphries P. Campbell M, et al. J Gene Med. 2008 Aug;10(8):930-47. doi: 10.1002/jgm.1211. J Gene Med. 2008. PMID: 18509865
An experimental platform for systemic drug delivery to the retina.
Campbell M, Nguyen AT, Kiang AS, Tam LC, Gobbo OL, Kerskens C, Ni Dhubhghaill S, Humphries MM, Farrar GJ, Kenna PF, Humphries P. Campbell M, et al. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17817-22. doi: 10.1073/pnas.0908561106. Epub 2009 Oct 12. Proc Natl Acad Sci U S A. 2009. PMID: 19822744 Free PMC article.
Protection of photoreceptors in a mouse model of RP10.
Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: campbell m. Adv Exp Med Biol. 2010;664:559-65. doi: 10.1007/978-1-4419-1399-9_64. Adv Exp Med Biol. 2010. PMID: 20238059
5,419 results