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Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.
Alcalá-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, Golbano A, Crespí-Vázquez K, Parry A, Slater G, Samarajiwa S, Peiró S, Di Croce L, Narita M, Pérez-Navarro E. Alcalá-Vida R, et al. Among authors: samarajiwa s. EMBO Mol Med. 2021 Feb 5;13(2):e12105. doi: 10.15252/emmm.202012105. Epub 2020 Dec 28. EMBO Mol Med. 2021. PMID: 33369245 Free PMC article.
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.
Kirschner K, Samarajiwa SA, Cairns JM, Menon S, Pérez-Mancera PA, Tomimatsu K, Bermejo-Rodriguez C, Ito Y, Chandra T, Narita M, Lyons SK, Lynch AG, Kimura H, Ohbayashi T, Tavaré S, Narita M. Kirschner K, et al. Among authors: samarajiwa sa. PLoS Genet. 2015 Mar 19;11(3):e1005053. doi: 10.1371/journal.pgen.1005053. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25790137 Free PMC article.
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.
Parry AJ, Hoare M, Bihary D, Hänsel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D'Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. Parry AJ, et al. Among authors: samarajiwa sa. Nat Commun. 2018 May 9;9(1):1840. doi: 10.1038/s41467-018-04283-9. Nat Commun. 2018. PMID: 29743479 Free PMC article.
Locus-specific induction of gene expression from heterochromatin loci during cellular senescence.
Tomimatsu K, Bihary D, Olan I, Parry AJ, Schoenfelder S, Chan ASL, Slater GSC, Ito Y, Rugg-Gunn PJ, Kirschner K, Bermejo-Rodriguez C, Seko T, Kugoh H, Shiraishi K, Sayama K, Kimura H, Fraser P, Narita M, Samarajiwa SA, Narita M. Tomimatsu K, et al. Among authors: samarajiwa sa. Nat Aging. 2022 Jan;2(1):31-45. doi: 10.1038/s43587-021-00147-y. Epub 2021 Dec 23. Nat Aging. 2022. PMID: 37118356
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
Holland DG, Burleigh A, Git A, Goldgraben MA, Perez-Mancera PA, Chin SF, Hurtado A, Bruna A, Ali HR, Greenwood W, Dunning MJ, Samarajiwa S, Menon S, Rueda OM, Lynch AG, McKinney S, Ellis IO, Eaves CJ, Carroll JS, Curtis C, Aparicio S, Caldas C. Holland DG, et al. Among authors: samarajiwa s. EMBO Mol Med. 2011 Mar;3(3):167-80. doi: 10.1002/emmm.201100122. Epub 2011 Feb 18. EMBO Mol Med. 2011. PMID: 21337521 Free PMC article.
Spatial coupling of mTOR and autophagy augments secretory phenotypes.
Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M, Tavaré S, Inoki K, Shimizu S, Narita M. Narita M, et al. Among authors: samarajiwa sa. Science. 2011 May 20;332(6032):966-70. doi: 10.1126/science.1205407. Epub 2011 Apr 21. Science. 2011. PMID: 21512002 Free PMC article.
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.
Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nũnez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, Narita M. Chandra T, et al. Among authors: samarajiwa sa. Mol Cell. 2012 Jul 27;47(2):203-14. doi: 10.1016/j.molcel.2012.06.010. Epub 2012 Jul 12. Mol Cell. 2012. PMID: 22795131 Free PMC article.
29 results