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Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
Cheng H, Orr STM, Bailey S, Brooun A, Chen P, Deal JG, Deng YL, Edwards MP, Gallego GM, Grodsky N, Huang B, Jalaie M, Kaiser S, Kania RS, Kephart SE, Lafontaine J, Ornelas MA, Pairish M, Planken S, Shen H, Sutton S, Zehnder L, Almaden CD, Bagrodia S, Falk MD, Gukasyan HJ, Ho C, Kang X, Kosa RE, Liu L, Spilker ME, Timofeevski S, Visswanathan R, Wang Z, Meng F, Ren S, Shao L, Xu F, Kath JC. Cheng H, et al. Among authors: kang x. J Med Chem. 2021 Jan 14;64(1):644-661. doi: 10.1021/acs.jmedchem.0c01652. Epub 2020 Dec 24. J Med Chem. 2021. PMID: 33356246
Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.
Grant S, Tran P, Zhang Q, Zou A, Dinh D, Jensen J, Zhou S, Kang X, Zachwieja J, Lippincott J, Liu K, Johnson SL, Scales S, Yin C, Nukui S, Stoner C, Prasanna G, Lafontaine J, Wells P, Li H. Grant S, et al. Among authors: kang x. Eur J Pharmacol. 2010 Feb 10;627(1-3):16-25. doi: 10.1016/j.ejphar.2009.10.029. Epub 2009 Oct 20. Eur J Pharmacol. 2010. PMID: 19850035
Monitoring cellular accumulation of 3'-deoxy-3'-fluorothymidine (FLT) and its monophosphate metabolite (FLT-MP) by LC-MS/MS as a measure of cell proliferation in vitro.
Li W, Araya M, Elliott M, Kang X, Gerk PM, Halquist MS, Karnes HT, Zhang C, O'Brien PJ. Li W, et al. Among authors: kang x. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 15;879(28):2963-70. doi: 10.1016/j.jchromb.2011.08.024. Epub 2011 Aug 31. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 21925976
PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib.
Ding X, Zhu Z, Lapek J, McMillan EA, Zhang A, Chung CY, Dubbury S, Lapira J, Firdaus S, Kang X, Gao J, Oyer J, Chionis J, Rollins RA, Li L, Niessen S, Bagrodia S, Zhang L, VanArsdale T. Ding X, et al. Among authors: kang x. Sci Rep. 2022 Jul 21;12(1):12501. doi: 10.1038/s41598-022-16623-3. Sci Rep. 2022. PMID: 35864202 Free PMC article.
4,117 results